LaRowe Lisa R, Bohlen Lauren Connell, Gaudiano Brandon A, Abrantes Ana M, Butryn Meghan L, Dunsiger Shira I, Griffin Elizabeth, Loucks Eric B, Uebelacker Lisa A, Williams David M
Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, 02903, USA.
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Ment Health Phys Act. 2022 Oct;23. doi: 10.1016/j.mhpa.2022.100475. Epub 2022 Oct 22.
Engaging in regular physical activity (PA) is particularly important among individuals with depression, who are at heightened risk for a host of negative health outcomes. However, people with depression are 50% less likely to meet national guidelines for PA and face unique barriers to PA adherence, including lower distress tolerance and motivation for exercise. Acceptance and Commitment Therapy (ACT) may offer promise for increasing PA among adults with depressive symptoms due to its effects on distress tolerance and motivation. Therefore, we developed ACTivity, an ACT-based intervention designed to promote PA among low-active adults with elevated depressive symptoms. Prior to testing the efficacy of ACTivity in an RCT, an important first step is to conduct a preliminary trial to establish feasibility of study procedures for the ACTivity and comparison intervention programs, as well as to establish the credibility/acceptability of the intervention. The purpose of this paper is to describe the ACTivity intervention and the design of this feasibility trial.
METHOD/DESIGN: We will conduct a feasibility RCT with two parallel groups and a 1:1 allocation ratio comparing ACTivity to a comparison intervention (relaxation training + PA promotion) among 60 low-active adults with elevated depressive symptoms. All study procedures will be conducted remotely.
Results of this feasibility study will inform a subsequent RCT designed to test the efficacy of ACTivity. If shown to be efficacious, ACTivity will provide a treatment that can be widely disseminated to increase PA among adults with depressive symptoms and thereby decrease their risk for chronic disease.
对于抑郁症患者而言,定期进行体育活动尤为重要,因为他们面临一系列负面健康结果的风险更高。然而,抑郁症患者达到国家体育活动指南要求的可能性要低50%,并且在坚持体育活动方面面临独特障碍,包括较低的痛苦耐受力和运动动机。接纳与承诺疗法(ACT)因其对痛苦耐受力和动机的影响,可能有望增加有抑郁症状成年人的体育活动量。因此,我们开发了ACTivity,这是一种基于ACT的干预措施,旨在促进抑郁症状加重的低运动量成年人的体育活动。在通过随机对照试验(RCT)测试ACTivity的疗效之前,重要的第一步是进行一项初步试验,以确定ACTivity和对照干预项目研究程序的可行性,以及确定干预措施的可信度/可接受性。本文的目的是描述ACTivity干预措施以及这项可行性试验的设计。
方法/设计:我们将进行一项可行性随机对照试验,设立两个平行组,分配比例为1:1,在60名抑郁症状加重的低运动量成年人中,将ACTivity与对照干预措施(放松训练+体育活动促进)进行比较。所有研究程序将通过远程方式进行。
这项可行性研究的结果将为后续旨在测试ACTivity疗效的随机对照试验提供信息。如果证明ACTivity有效,它将提供一种可广泛推广的治疗方法,以增加有抑郁症状成年人的体育活动量,从而降低他们患慢性病的风险。