Taşkıran Mehmet
Urology, Özel Hatem Hastanesi, Gaziantep, TUR.
Cureus. 2023 Aug 29;15(8):e44339. doi: 10.7759/cureus.44339. eCollection 2023 Aug.
Oxidative stress is known as a mechanism underlying male infertility; it is defined as an imbalance between pro-oxidants and antioxidants leading to DNA damage, peroxidation of plasma membrane lipids, and protein oxidation. This study was conducted to investigate the relationship between total antioxidant capacity and sperm parameters in male infertility.
A total of 187 men with infertility (asthenospermia group (n=51), oligospermia group (n=40), and control group (n=96) were included in the current study. The following risk factors were recorded: age, sperm volume, sperm motility, hormone levels, and dietary antioxidant content.
Demographic parameters and hormone levels of cases showed no statistically significant difference between groups (p > 0.05). Semen volume, motility, vitamin A, retinol, vitamin D, and vitamin C levels were statistically significantly lower in the asthenospermia and oligospermia groups (p < 0.05). According to the logistic regression model, lower vitamin A, retinol, vitamin D, and vitamin C levels were risk factors for poor sperm outcomes (p < 0.001). Conclusıon: Male infertility with poor sperm outcomes should have an assessment of antioxidant capacity and nutritional specialization including food high in antioxidants could improve sperm parameters in asthenospermia and oligospermia and it could be used for therapeutic opportunities.
氧化应激被认为是男性不育的潜在机制；它被定义为促氧化剂和抗氧化剂之间的失衡，导致DNA损伤、质膜脂质过氧化和蛋白质氧化。本研究旨在探讨男性不育患者总抗氧化能力与精子参数之间的关系。
本研究共纳入187名不育男性（弱精子症组（n = 51）、少精子症组（n = 40）和对照组（n = 96））。记录以下危险因素：年龄、精液量、精子活力、激素水平和膳食抗氧化剂含量。
病例组的人口统计学参数和激素水平在各组之间无统计学显著差异（p > 0.05）。弱精子症组和少精子症组的精液量、活力、维生素A、视黄醇、维生素D和维生素C水平在统计学上显著较低（p < 0.05）。根据逻辑回归模型，较低的维生素A、视黄醇、维生素D和维生素C水平是精子质量差的危险因素（p < 0.001）。结论：精子质量差的男性不育患者应评估抗氧化能力，包括富含抗氧化剂的食物在内的营养专业化可改善弱精子症和少精子症患者的精子参数，并可用于治疗机会。
