Rodriguez-Archilla Alberto, Gomez-Fernandez Marina
Department of Stomatology, Oral Medicine Unit. Faculty of Dentistry. University of Granada, Granada, Spain.
J Dent Res Dent Clin Dent Prospects. 2023 Winter;17(1):1-7. doi: 10.34172/joddd.2023.36851. Epub 2023 Apr 3.
The role of dairy product consumption on oral cancer risk is not yet fully clarified. Some studies have observed an inverse association between dairy consumption and oral cancer risk. This study aimed to determine the influence of dairy product consumption (milk, cheese, yogurt, butter) on oral cancer risk.
A search for studies on dairy products and oral cancer was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Scopus. The estimation of the odds ratio (OR) effect was performed with the generic inverse variance method using the logarithm of the effect with the standard error (SE) and 95% confidence intervals.
Twenty-one studies with 59271 participants (8,300 oral cancer patients and 50971 controls) were included in this meta-analysis. All dairy products significantly reduced oral cancer risk except butter (=0.16). Milk intake reduced oral cancer risk by 27% (OR: 0.73; <0.001); yogurt consumption by 25% (OR: 0.75; <0.001), and cheese consumption by 21% (OR:0.79; <0.01).
Regular consumption of dairy products reduces oral cancer risk between 21% and 27%.
乳制品消费对口腔癌风险的作用尚未完全阐明。一些研究观察到乳制品消费与口腔癌风险之间存在负相关。本研究旨在确定乳制品消费（牛奶、奶酪、酸奶、黄油）对口腔癌风险的影响。
在以下数据库中检索关于乳制品与口腔癌的研究：PubMed（MEDLINE、Cochrane图书馆）、科学网（WoS）和Scopus。使用效应对数与标准误差（SE）及95%置信区间，通过通用逆方差法对优势比（OR）效应进行估计。
本荟萃分析纳入了21项研究，共59271名参与者（8300名口腔癌患者和50971名对照）。除黄油外（=0.16），所有乳制品均显著降低了口腔癌风险。摄入牛奶使口腔癌风险降低27%（OR：0.73；<0.001）；食用酸奶降低25%（OR：0.75；<0.001），食用奶酪降低21%（OR：0.79；<0.01）。
经常食用乳制品可使口腔癌风险降低21%至27%。
