Faculty of Medicine & Defence Health, Universiti Pertahanan Nasional Malaysia, Kuala Lumpur, Malaysia.
Department of Medical Microbiology & Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Trop Biomed. 2023 Jun 1;40(2):170-173. doi: 10.47665/tb.40.2.007.
Vibrio cholerae is a gram-negative bacterium synonymous with its namesake disease, cholera. Thus, gastrointestinal symptoms are the norm and V. cholerae is very rarely associated with skin and soft tissue infections. We describe a case of a 63-year-old Chinese woman with multiple medical comorbidities on corticosteroid therapy who developed fever and a painful swelling on her left leg after being pricked by a branch while gardening. There was no abdominal pain, vomiting or diarrhea. A diagnosis of bullous cellulitis was made clinically, and blood was sent for bacteriological culture. A beta-hemolytic commashaped gram-negative bacillus was isolated from the blood. It was also oxidase-positive and produced an acid/alkaline (A/K) reaction on triple sugar iron agar. It was identified biochemically as Vibrio cholerae. After additional testing, it was found to be of the O1 serogroup and Ogawa serotype. The infection resolved following a 10-day course of high-dose co-trimoxazole therapy.
霍乱弧菌是一种革兰氏阴性细菌，与它的同名疾病霍乱同义。因此，胃肠道症状是常见的，霍乱弧菌很少与皮肤和软组织感染有关。我们描述了一例 63 岁的中国妇女，她因患有多种医学合并症而接受皮质类固醇治疗，在园艺时被树枝刺伤左腿后出现发热和疼痛性肿胀。她没有腹痛、呕吐或腹泻。临床诊断为大疱性蜂窝织炎，并采集血液进行细菌培养。从血液中分离出一种β溶血呈逗号形革兰氏阴性杆菌。它还呈氧化酶阳性，在三糖铁琼脂上产生酸/碱性（A/K）反应。该菌经生化鉴定为霍乱弧菌。经过进一步检测，发现它属于 O1 血清群和 Ogawa 血清型。在接受 10 天高剂量复方磺胺甲噁唑治疗后，感染得到了治愈。
