Ophthalmology Department, Boston Children's Hospital, Boston, Massachusetts, United States.
Ophthalmology Department, Harvard Medical School, Boston, Massachusetts, United States.
Invest Ophthalmol Vis Sci. 2023 Aug 1;64(11):35. doi: 10.1167/iovs.64.11.35.
The purpose of this study was to test the hypothesis that retinopathy of prematurity (ROP) prolongs development of rod-mediated thresholds for detection of stimuli at 10 degrees but not 30 degrees eccentricity. In addition, to evaluate the thresholds at each site for an association with visual acuity (VA) and spherical equivalent (SE).
We estimated rod-mediated dark-adapted thresholds (DATs) for the detection of 2 degree diameter, 50 ms, blue (λ < 510 nm) flashes at 10 degrees and 30 degrees eccentric in former preterm subjects (n = 111), stratified by ROP severity: None (n = 32), Mild (n = 66), and Severe (n = 13). We also tested Term-born (n = 28) controls. To determine the age at half-maximal sensitivity (Agehalf) for each group and eccentricity, we fit DATs to logistic growth curves. We obtained VA and SE for Preterm subjects and evaluated the course of threshold development at 10 degrees and 30 degrees for significant association with VA and SE predicted at age 10 years.
DAT development at 10 degrees was significantly delayed in ROP (Mild and Severe); ROP did not significantly alter DAT development at 30 degrees. At age 10 years, among Preterm subjects, both VA and SE were significantly associated with group (None,Mild, and Severe). SE was predicted by the course of DAT development at 30 degrees. VA was not associated with the course of DAT development at 10 degrees.
At 10 degrees, ROP-whether mild or severe-is associated with significant delays in DAT development, evidence that the late-maturing central retina is vulnerable to ROP. The association of 30 degree threshold and myopia are evidence that more peripheral retina is important to refractive development.
本研究旨在验证这样一个假设，即早产儿视网膜病变（ROP）会延长杆状细胞介导的检测刺激的阈值，这种刺激位于 10 度而不是 30 度的外周视野。此外，评估每个部位的阈值与视力（VA）和等效球镜（SE）的相关性。
我们估计了前早产儿（n = 111）的暗适应杆状细胞阈值（DAT），用于检测 2 度直径、50 毫秒、蓝色（λ < 510nm）闪光，刺激位于 10 度和 30 度的外周视野，根据 ROP 严重程度进行分层：无（n = 32）、轻度（n = 66）和重度（n = 13）。我们还测试了足月出生（n = 28）的对照组。为了确定每个组和每个偏心距的半最大敏感性（Agehalf）年龄，我们将 DAT 拟合到逻辑增长曲线中。我们获得了早产儿的 VA 和 SE，并评估了 10 度和 30 度阈值的发展过程，以确定其与 10 岁时预测的 VA 和 SE 之间的显著关联。
ROP（轻度和重度）使 10 度的 DAT 发育显著延迟；ROP 并没有显著改变 30 度的 DAT 发育。在 10 岁时，早产儿的 VA 和 SE 与组（无、轻度和重度）均有显著相关性。SE 可由 30 度 DAT 发育的过程来预测。VA 与 10 度 DAT 发育的过程无关。
在 10 度时，无论是轻度还是重度 ROP，都与 DAT 发育的显著延迟有关，这表明发育较晚的中央视网膜容易受到 ROP 的影响。30 度阈值与近视的相关性表明，更外周的视网膜对屈光发育很重要。
