Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
Biomed Pharmacother. 2023 Oct;166:115401. doi: 10.1016/j.biopha.2023.115401. Epub 2023 Aug 29.
Lipid metabolism is a complex process that maintains the normal physiological function of the human body. The disorder of lipid metabolism has been implicated in various human diseases, such as cardiovascular diseases and bone diseases. Intervertebral disc degeneration (IDD), an age-related degenerative disease in the musculoskeletal system, is characterized by high morbidity, high treatment cost, and chronic recurrence. Lipid metabolism disorder may promote the pathogenesis of IDD, and the potential mechanisms are complex. Leptin, resistin, nicotinamide phosphoribosyltransferase (NAMPT), fatty acids, and cholesterol may promote the pathogenesis of IDD, while lipocalin, adiponectin, and progranulin (PGRN) exhibit protective activity against IDD development. Lipid metabolism disorder contributes to extracellular matrix (ECM) degradation, cell apoptosis, and cartilage calcification in the intervertebral discs (IVDs) by activating inflammatory responses, endoplasmic reticulum (ER) stress, and oxidative stress and inhibiting autophagy. Several lines of agents have been developed to target lipid metabolism disorder. Inhibition of lipid metabolism disorder may be an effective strategy for the therapeutic management of IDD. However, an in-depth understanding of the molecular mechanism of lipid metabolism disorder in promoting IDD development is still needed.
脂质代谢是维持人体正常生理功能的复杂过程。脂质代谢紊乱与心血管疾病和骨骼疾病等多种人类疾病有关。椎间盘退变（IDD）是一种与年龄相关的骨骼肌肉系统退行性疾病，其发病率高、治疗费用高、慢性复发。脂质代谢紊乱可能促进 IDD 的发病机制，其潜在机制复杂。瘦素、抵抗素、烟酰胺磷酸核糖转移酶（NAMPT）、脂肪酸和胆固醇可能促进 IDD 的发病机制，而脂联素、瘦素和颗粒体蛋白（PGRN）对 IDD 的发展具有保护作用。脂质代谢紊乱通过激活炎症反应、内质网（ER）应激和氧化应激以及抑制自噬，促进椎间盘（IVD）细胞外基质（ECM）降解、细胞凋亡和软骨钙化。已经开发了几种针对脂质代谢紊乱的药物。抑制脂质代谢紊乱可能是治疗 IDD 的有效策略。然而，仍需要深入了解脂质代谢紊乱促进 IDD 发展的分子机制。
