Silverman R H, Coleman D J, Lizzi F L, Torpey J H, Driller J, Iwamoto T, Burgess S E, Rosado A
Ultrasound Med Biol. 1986 Aug;12(8):639-45. doi: 10.1016/0301-5629(86)90185-7.
Cells derived from human skin malignant melanoma were implanted subcutaneously in athymic nude mice. Tumors which developed at the implant site were treated with ultrasonically induced hyperthermia at 49 degrees C for 30 min. Tumors were scanned with a computerized diagnostic ultrasound system before and after treatment. Light (LM) and electron (EM) micrographs of tumors were obtained after scanning. Changes in ultrasonic tissue characterization parameters following treatment were well correlated with histopathologic changes observed in tumors. The results are significant in terms of clinical application of ultrasonically induced hyperthermia for treatment of intraocular tumors and the noninvasive monitoring of tumors by use of diagnostic ultrasound.
将源自人类皮肤恶性黑色素瘤的细胞皮下植入无胸腺裸鼠体内。在植入部位长出的肿瘤用49摄氏度的超声诱导热疗处理30分钟。治疗前后用计算机诊断超声系统对肿瘤进行扫描。扫描后获取肿瘤的光镜（LM）和电镜（EM）显微照片。治疗后超声组织特征参数的变化与肿瘤中观察到的组织病理学变化密切相关。这些结果对于超声诱导热疗在眼内肿瘤治疗中的临床应用以及利用诊断超声对肿瘤进行无创监测具有重要意义。
