Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Int J Biol Macromol. 2023 Dec 31;253(Pt 2):126581. doi: 10.1016/j.ijbiomac.2023.126581. Epub 2023 Aug 29.
Carbohydrate polymers-based surface-modified nano-delivery systems have gained significant attention in recent years for enhancing targeted delivery to colon cancer. These systems leverage carbohydrate polymers' unique properties, such as biocompatibility, biodegradability, and controlled release. These properties make them suitable candidates for drug delivery applications. Nano-delivery systems loaded with bioactive compounds are well-studied for targeted colorectal cancer delivery. However, those drugs' target reach is still limited in various nano-delivery systems. To overcome this limitation, surface modification of nanoparticles with carbohydrate polymers like chitosan, pectin, alginate, and guar gum showed enhanced target-reaching capacity along with enhanced anticancer efficacy. Recently, a chitosan-decorated PLGA nanoparticle was constructed with tannic acid and vitamin E and showed long-term release of specific targets along with higher anticancer efficacy. Similarly, Chitosan-conjugated glucuronic acid-coated silica nanoparticles loaded with capecitabine were studied against colon cancer and found to be the pH-responsive controlled release of capecitabine with higher anticancer efficacy. Surface-modified carbohydrate polymers have promising potential for improving colon cancer target delivery. By leveraging the unique properties of these polymers, such as surface modification, pH responsiveness, mucoadhesion, controlled drug release, and combination therapy, researchers are working toward developing more effective and targeted treatment strategies for colon cancer.
基于碳水化合物聚合物的表面修饰纳米递药系统近年来在增强结肠癌靶向递送上引起了广泛关注。这些系统利用碳水化合物聚合物的独特性质，如生物相容性、可生物降解性和控制释放性。这些性质使它们成为药物递送应用的合适候选物。负载生物活性化合物的纳米递药系统已被广泛研究用于靶向结直肠癌细胞的递药。然而，这些药物在各种纳米递药系统中的靶向到达仍然有限。为了克服这一限制，用壳聚糖、果胶、藻酸盐和瓜尔胶等碳水化合物聚合物对纳米颗粒进行表面修饰，显示出增强的靶向能力和增强的抗癌功效。最近，构建了一种用单宁酸和维生素 E 修饰的壳聚糖-PLGA 纳米颗粒，具有长期释放特定靶标和更高抗癌功效的特点。同样，壳聚糖-结合的葡萄糖醛酸-涂层的载有卡培他滨的二氧化硅纳米颗粒也被用于研究结肠癌，并发现其具有 pH 响应性的卡培他滨控制释放和更高的抗癌功效。表面修饰的碳水化合物聚合物在改善结肠癌靶向递送上具有广阔的应用前景。通过利用这些聚合物的独特性质，如表面修饰、pH 响应性、黏膜黏附性、控制药物释放和联合治疗，研究人员正在努力开发更有效和更有针对性的结肠癌治疗策略。
