Thamarai Packiyam, Karishma Suresh, Kamalesh Raja, Shaji Alan, Saravanan Anbalagan, Bibi Shabana, Vickram Agaram Sundaram, Chopra Hitesh, Saleem Rimah A, Alsharif Khalaf F, Theyab Abdulrahman, Kamel Mohamed, Alamoudi Mariam K, Kumer Ajoy, Chopra Shivani, Abdel-Daim Mohamed M
Department of Biotechnology, Saveetha School of Engineering, SIMATS, Chennai, India.
Department of Biosciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Int J Surg. 2024 Dec 1;110(12):7456-7476. doi: 10.1097/JS9.0000000000002082.
Stem cell therapy has emerged as a promising approach for regenerative medicine, offering potential treatments for a wide range of diseases and injuries. Although stem cell therapy has great promise, several obstacles have prevented its broad clinical adoption. The effectiveness of therapy has been inhibited by problems such as ineffective stem cell differentiation, low post-transplantation survival rates, and restricted control over stem cell behavior. Furthermore, the implementation of stem cell therapies is further complicated by the possibility of immunological rejection and cancer. Innovative strategies that provide precise control over stem cell characteristics and maximize their therapeutic potential are desperately needed to overcome these obstacles. Recent studies have shown that the effectiveness of stem cell treatments can be greatly increased by nanoscale advances. By establishing an ideal microenvironment and precisely offering growth factors, nanomaterials such as nanoparticles, nanocomposites, and quantum dots have been demonstrated to improve stem cell differentiation and proliferation. This article provides an overview of the recent trends and applications of nanoscale innovations in the context of stem cell therapy. The recent development of precision medicine has been facilitated by the incorporation of nanotechnology into stem cell therapy. The ability to manipulate stem cells at the nanoscale offers unprecedented control over their behavior and function, opening up exciting possibilities for personalized and highly effective therapeutic interventions. This review paper highlights the recent trends and applications of nanotechnology in advancing stem cell therapy, showcasing its potential to revolutionize regenerative medicine.
干细胞疗法已成为再生医学中一种很有前景的方法，为多种疾病和损伤提供了潜在的治疗手段。尽管干细胞疗法前景广阔，但仍有几个障碍阻碍了其在临床上的广泛应用。治疗效果受到诸如干细胞分化无效、移植后存活率低以及对干细胞行为控制受限等问题的抑制。此外，免疫排斥和癌症的可能性使干细胞疗法的实施更加复杂。迫切需要创新策略来精确控制干细胞特性并最大化其治疗潜力，以克服这些障碍。最近的研究表明，纳米技术的进步可以大大提高干细胞治疗的效果。通过建立理想的微环境并精确提供生长因子，诸如纳米颗粒、纳米复合材料和量子点等纳米材料已被证明可以改善干细胞的分化和增殖。本文概述了纳米技术创新在干细胞治疗背景下的最新趋势和应用。将纳米技术融入干细胞治疗推动了精准医学的最新发展。在纳米尺度上操纵干细胞的能力为其行为和功能提供了前所未有的控制，为个性化和高效的治疗干预开辟了令人兴奋的可能性。这篇综述文章强调了纳米技术在推进干细胞治疗方面的最新趋势和应用，展示了其变革再生医学的潜力。
