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全身灌注成像技术与 [C]-正丁醇。

Total-Body Perfusion Imaging with [C]-Butanol.

机构信息

Department of Biomedical Engineering, UC Davis, Davis, California.

Department of Internal Medicine, Division of Cardiovascular Medicine, UC Davis Health, UC Davis, Sacramento, California; and.

出版信息

J Nucl Med. 2023 Nov;64(11):1831-1838. doi: 10.2967/jnumed.123.265659. Epub 2023 Aug 31.

DOI:10.2967/jnumed.123.265659
PMID:37652544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10626376/
Abstract

Tissue perfusion can be affected by physiology or disease. With the advent of total-body PET, quantitative measurement of perfusion across the entire body is possible. [C]-butanol is a perfusion tracer with a superior extraction fraction compared with [O]-water and [N]-ammonia. To develop the methodology for total-body perfusion imaging, a pilot study using [C]-butanol on the uEXPLORER total-body PET/CT scanner was conducted. Eight participants (6 healthy volunteers and 2 patients with peripheral vascular disease [PVD]) were injected with a bolus of [C]-butanol and underwent 30-min dynamic acquisitions. Three healthy volunteers underwent repeat studies at rest (baseline) to assess test-retest reproducibility; 1 volunteer underwent paired rest and cold pressor test (CPT) studies. Changes in perfusion were measured in the paired rest-CPT study. For PVD patients, local changes in perfusion were investigated and correlated with patient medical history. Regional and parametric kinetic analysis methods were developed using a 1-tissue compartment model and leading-edge delay correction. Estimated baseline perfusion values ranged from 0.02 to 1.95 mL·min·cm across organs. Test-retest analysis showed that repeat baseline perfusion measurements were highly correlated (slope, 0.99; Pearson = 0.96, < 0.001). For the CPT subject, the largest regional increases were in skeletal muscle (psoas, 142%) and the myocardium (64%). One of the PVD patients showed increased collateral vessel growth in the calf because of a peripheral stenosis. Comorbidities including myocardial infarction, hypothyroidism, and renal failure were correlated with variations in organ-specific perfusion. This pilot study demonstrates the ability to obtain reproducible measurements of total-body perfusion using [C]-butanol. The methods are sensitive to local perturbations in flow because of physiologic stressors and disease.

摘要

组织灌注可受到生理或疾病的影响。随着全身 PET 的出现,对整个身体的灌注进行定量测量成为可能。与 [O]-水和 [N]-氨相比,[C]-丁醇是一种具有更高提取分数的灌注示踪剂。为了开发全身灌注成像的方法,在 uEXPLORER 全身 PET/CT 扫描仪上使用 [C]-丁醇进行了一项试点研究。 8 名参与者(6 名健康志愿者和 2 名外周血管疾病 [PVD] 患者)静脉注射 [C]-丁醇后进行了 30 分钟的动态采集。3 名健康志愿者在休息时(基线)进行了重复研究,以评估测试-重测的可重复性;1 名志愿者进行了配对的休息和冷加压试验(CPT)研究。在配对的休息-CPT 研究中测量灌注变化。对于 PVD 患者,研究了局部灌注变化,并与患者病史相关联。使用 1 组织隔室模型和前沿延迟校正开发了区域和参数动力学分析方法。 估计的基线灌注值在器官之间的范围为 0.02 至 1.95 mL·min·cm。测试-重测分析表明,重复基线灌注测量高度相关(斜率,0.99;Pearson = 0.96,<0.001)。对于 CPT 受试者,最大的区域性增加发生在骨骼肌(腰大肌,142%)和心肌(64%)。1 名 PVD 患者由于外周狭窄导致小腿侧支血管生长增加。包括心肌梗死、甲状腺功能减退和肾衰竭在内的合并症与特定器官灌注的变化相关。 这项试点研究表明,使用 [C]-丁醇能够获得重复性的全身灌注测量值。该方法对由于生理应激和疾病引起的局部血流变化敏感。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc6/10626376/2c55e5b452a1/jnumed.123.265659absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc6/10626376/2c55e5b452a1/jnumed.123.265659absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc6/10626376/2c55e5b452a1/jnumed.123.265659absf1.jpg

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