Hricak Hedvig, Mayerhoefer Marius E, Herrmann Ken, Lewis Jason S, Pomper Martin G, Hess Christopher P, Riklund Katrine, Scott Andrew M, Weissleder Ralph
Department of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Lancet Oncol. 2025 Jan;26(1):e34-e45. doi: 10.1016/S1470-2045(24)00395-4.
Technological innovations in genomics and related fields have facilitated large sequencing efforts, supported new biological discoveries in cancer, and spawned an era of liquid biopsy biomarkers. Despite these advances, precision oncology has practical constraints, partly related to cancer's biological diversity and spatial and temporal complexity. Advanced imaging technologies are being developed to address some of the current limitations in early detection, treatment selection and planning, drug delivery, and therapeutic response, as well as difficulties posed by drug resistance, drug toxicity, disease monitoring, and metastatic evolution. We discuss key areas of advanced imaging for improving cancer outcomes and survival. Finally, we discuss practical challenges to the broader adoption of precision imaging in the clinic and the need for a robust translational infrastructure.
基因组学及相关领域的技术创新推动了大规模测序工作，助力了癌症领域的新生物学发现，并催生了液体活检生物标志物的时代。尽管取得了这些进展，但精准肿瘤学仍存在实际限制，部分原因与癌症的生物多样性以及时空复杂性有关。先进的成像技术正在不断发展，以解决早期检测、治疗选择与规划、药物递送、治疗反应等方面当前存在的一些局限性，以及耐药性、药物毒性、疾病监测和转移演变所带来的难题。我们讨论了先进成像技术在改善癌症治疗效果和生存率方面的关键领域。最后，我们探讨了精准成像在临床更广泛应用所面临的实际挑战以及建立强大转化基础设施的必要性。
