Department of Hematology and Hematopoietic Cell Transplantation (T Cell Therapeutics Research Laboratories), City of Hope, Beckman Research Institute and Medical Center, Duarte, CA 91010, USA.
Department of Hematology and Hematopoietic Cell Transplantation (T Cell Therapeutics Research Laboratories), City of Hope, Beckman Research Institute and Medical Center, Duarte, CA 91010, USA.
Trends Immunol. 2023 Oct;44(10):748-750. doi: 10.1016/j.it.2023.08.002. Epub 2023 Aug 29.
Broadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.
通过抗原扩散来拓宽免疫反应仍然是癌症免疫治疗的“圣杯”。马及其同事的一项研究表明，在小鼠中增强嵌合抗原受体 (CAR)-T 细胞的疫苗会促进内源性免疫，并通过一种关键依赖于干扰素 (IFN)γ的机制引发抗原扩散，从而消除抗原异质性的实体瘤。
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