Hart S, Wrathmell A B, Harris J E
Vet Immunol Immunopathol. 1986 Jun;12(1-4):107-16. doi: 10.1016/0165-2427(86)90115-7.
Cartilaginous fish occupy a fundamental position in vertebrate phylogeny and it is likely that this group has retained some of the ancestral immune mechanisms. The ontogeny of GALT has received little attention in elasmobranchs and this study correlates this development with morphological differentiation, development of other lymphoid organs, exposure to seawater and transition from yolk dependence to exogenous food as a source of nutrient. GALT was first represented by individual lymphocyte-like and macrophage-like cells in the lamina propria. In later stages accumulations and intraepithelial leucocytes were recorded prior to hatching. The size of accumulations and the number of lymphocyte and macrophage-like cells infiltrating the lamina propria and epithelium increased in fish as they became dependent upon an exogenous diet. Although GALT developed after the thymus and lymphoid-like tissue in the kidney and at approximately the same time as the epigonal, Leydig and spleen, the source of cells populating the gut is unknown. Plasma cells and granulocytes were not observed in the developing fish until 6 months post-hatch after which the fish had a similar GALT distribution and content to the adult fish.
软骨鱼在脊椎动物系统发育中占据着重要地位，并且很可能该类群保留了一些原始的免疫机制。在板鳃亚纲动物中，肠道相关淋巴组织（GALT）的个体发生很少受到关注，本研究将这种发育与形态分化、其他淋巴器官的发育、接触海水以及从依赖卵黄到以外部食物作为营养来源的转变联系起来。GALT最初表现为固有层中单个淋巴细胞样和巨噬细胞样细胞。在后期阶段，孵化前记录到了细胞聚集和上皮内白细胞。随着鱼类开始依赖外部食物，固有层和上皮中细胞聚集的大小以及淋巴细胞样和巨噬细胞样细胞的数量增加。尽管GALT在胸腺和肾脏中的类淋巴组织之后发育，并且与性腺、莱迪希氏器官和脾脏大约同时发育，但填充肠道的细胞来源尚不清楚。在孵化后6个月之前，发育中的鱼类中未观察到浆细胞和粒细胞，之后鱼类的GALT分布和含量与成年鱼相似。
