Lloyd-Evans P
Department of Biological Sciences, University College of North Wales Bangor, Gwynedd, U.K.
Dev Comp Immunol. 1993 Nov-Dec;17(6):501-14. doi: 10.1016/s0145-305x(05)80006-0.
Previous studies on the morphology of the lymphomyeloid tissues in the dogfish, Scyliorhinus canicula, have been confined to adults. This study was restricted to the structure and functioning of the developing immune system in embryonic and post-hatch dogfish. A major feature of the developing immune system in S. canicula, is the succession of haemopoietic/lymphoid tissues. The liver is the first tissue to contain immunoglobulin positive cells at 2 months, followed by the interstitial kidney at 3 months. The thymus, spleen, and Leydig organ appears at 4 months while the epigonal and gut-associated lymphomyeloid tissues are the last tissues to differentiate. The haemopoietic/lymphoid nature of the kidney and thymus disappear at post-hatch and the other lymphomyeloid tissues persist through adult life. By the time of egg case splitting (ca. 6 months), when embryos receive massive exposure to water-borne antigens, the structural development of most of the lymphomyeloid tissues is well advanced.
以往对小斑猫鲨（Scyliorhinus canicula）淋巴髓样组织形态学的研究仅限于成体。本研究则聚焦于小斑猫鲨胚胎期及孵化后免疫系统的发育结构与功能。小斑猫鲨发育中的免疫系统的一个主要特征是造血/淋巴组织的相继出现。肝脏是在2个月时首个含有免疫球蛋白阳性细胞的组织，其次是3个月时的间质肾。胸腺、脾脏和莱迪希器官在4个月时出现，而性腺旁和肠道相关淋巴髓样组织是最后分化的组织。肾脏和胸腺的造血/淋巴特性在孵化后消失，其他淋巴髓样组织则持续至成年期。到卵壳裂开时（约6个月），胚胎大量接触水中抗原，此时大多数淋巴髓样组织的结构发育已相当完善。
