精子自身抗体和睾丸致敏白细胞衍生因子在体外诱导虹鳟巨噬细胞的免疫激活。
Immunological activation of rainbow trout macrophages induced in vitro by sperm autoantibodies and factors derived from testis sensitised leucocytes.
作者信息
Secombes C J
出版信息
Vet Immunol Immunopathol. 1986 Jun;12(1-4):193-201. doi: 10.1016/0165-2427(86)90123-6.
Young cultures of rainbow trout macrophages were found to significantly increase in diameter following addition of muramyl dipeptide or of supernatants from testis/FCA sensitised leucocytes incubated with spermatozoa, or a testis extract. However, such supernatants caused little migration inhibition or increase in phagocytosis of spermatozoa by macrophages, whereas opsonization of spermatozoa with anti-sperm serum caused an almost six-fold increase in phagocytosis. These results suggest an interplay between humoral and cell-mediated immune reactions upon macrophages during experimental autoimmunity to the testis in trout.
研究发现，在添加胞壁酰二肽、与精子共同孵育的睾丸/弗氏完全佐剂致敏白细胞的上清液或睾丸提取物后，虹鳟巨噬细胞的幼龄培养物直径显著增加。然而，这些上清液对巨噬细胞抑制精子迁移或增加其吞噬作用的影响很小，而用抗精子血清调理精子后，吞噬作用几乎增加了六倍。这些结果表明，在虹鳟对睾丸的实验性自身免疫过程中，体液免疫反应和细胞介导的免疫反应在巨噬细胞上存在相互作用。
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