Honda A, Kodama H, Moustafa M, Yamada F, Mikami T, Izawa H
Res Vet Sci. 1986 May;40(3):328-32.
The phagocytosis of Vibrio anguillarum by peritoneal macrophages from normal rainbow trout was enhanced by antibody and complement. Treatment of either macrophages or the bacteria by antibody also enhanced opsonisation. Five weeks after immunisation with V anguillarum, the phagocytic activity of macrophages from rainbow trout was increased significantly compared with the activity of those from unvaccinated fish. Although agglutinin titres did not increase until three weeks after immunisation, seven out of 10 fish challenged one week after immunisation survived, indicating that immunised fish had developed resistance to vibrio infection before significant levels of antibody or phagocytic activity became detectable.
正常虹鳟鱼腹膜巨噬细胞对鳗弧菌的吞噬作用可被抗体和补体增强。用抗体处理巨噬细胞或细菌也能增强调理作用。用鳗弧菌免疫五周后，虹鳟鱼巨噬细胞的吞噬活性与未接种疫苗鱼的巨噬细胞相比显著增加。虽然凝集素滴度直到免疫后三周才升高，但在免疫后一周受到攻击的10条鱼中有7条存活，这表明免疫鱼在可检测到显著水平的抗体或吞噬活性之前就已对弧菌感染产生了抗性。
