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自身抗体在虹鳟（萨氏虹鳟）对睾丸的自身免疫反应中的作用。

Role of autoantibodies in the autoimmune response to testis in rainbow trout (Salmo gairdneri).

作者信息

Secombes C J, Lewis A E, Laird L M, Needham E A, Priede I G

出版信息

Immunology. 1985 Nov;56(3):409-15.

PMID:4077096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453749/
Abstract

Rainbow trout, Salmo gairdneri, passively immunized with anti-sperm antibodies developed lesions in the testis characteristic of autoimmune attack. Only animals pre-treated with Freund's complete adjuvant developed these lesions. Investigations into the possible role of autoantibodies during autoimmune attack, carried out in vitro, showed that sperm antibodies were not cytotoxic but did have an opsonic effect on macrophage phagocytosis of sperm in the presence of complement.

摘要

用抗精子抗体进行被动免疫的虹鳟鱼（Salmo gairdneri）出现了具有自身免疫攻击特征的睾丸损伤。只有预先用弗氏完全佐剂处理过的动物才出现这些损伤。在体外对自身免疫攻击过程中自身抗体可能发挥的作用进行的研究表明，精子抗体没有细胞毒性，但在补体存在的情况下，对巨噬细胞吞噬精子具有调理作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab21/1453749/0c9cf3f075bc/immunology00188-0030-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab21/1453749/fe13f2bed079/immunology00188-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab21/1453749/0c9cf3f075bc/immunology00188-0030-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab21/1453749/fe13f2bed079/immunology00188-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab21/1453749/0c9cf3f075bc/immunology00188-0030-b.jpg

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本文引用的文献

1
The complement system of rainbow trout (Salmo gairdneri). I. Identification of the serum lytic system homologous to mammalian complement.虹鳟鱼（鲑鱼）的补体系统。I. 与哺乳动物补体同源的血清溶解系统的鉴定。
J Immunol. 1981 Apr;126(4):1489-94.
2
Requirement of B lymphocytes in local adoptive transfer of experimental allergic orchitis (EAO) by lymph node cells.淋巴结细胞局部过继转移实验性变应性睾丸炎（EAO）中B淋巴细胞的需求
Am J Reprod Immunol (1980). 1984 Oct-Nov;6(3):85-91. doi: 10.1111/j.1600-0897.1984.tb00120.x.
3
Attachment and phagocytosis by salmon macrophages of agarose beads coated with human C3b and C3bi.
鲑鱼巨噬细胞对包被有人 C3b 和 C3bi 的琼脂糖珠的黏附与吞噬作用。
Dev Comp Immunol. 1984 Summer;8(3):623-30. doi: 10.1016/0145-305x(84)90094-6.
4
Induction of autoimmune aspermatogenesis by noncellular cytophilic material.非细胞嗜细胞物质诱导自身免疫性精子发生
Folia Biol (Praha). 1969;15(3):173-80.
5
Induction of experimental autoimmune aspermatogenesis by immune serum fractions.免疫血清组分诱导实验性自身免疫性无精子症
Folia Biol (Praha). 1970;16(5):320-9.
6
Induction of aspermatogenesis by passive transfer of immune sera or cells.通过免疫血清或细胞的被动转移诱导无精子发生。
Int Arch Allergy Appl Immunol. 1972;43(2):172-81. doi: 10.1159/000230835.
7
Pathogenesis of experimental allergic orchitis. II. The role of antibody.实验性变应性睾丸炎的发病机制。II. 抗体的作用。
J Immunol. 1971 Jun;106(6):1463-72.
8
Spermatotoxic, spermagglutinating and cytotoxic activities of guinea-pig autoantibodies to sperm autoantigen T.豚鼠针对精子自身抗原T的自身抗体的精子毒性、精子凝集活性及细胞毒性作用
J Reprod Fertil. 1974 Apr;37(2):299-313. doi: 10.1530/jrf.0.0370299.
9
Passive transfer of autoimmune aspermogenic orchiepididymitis (AIAO) by antispermatozoa sera. Influence of the type of autoantigen and of the class of antibody.抗精子血清对自身免疫性致精子缺乏性睾丸炎附睾炎（AIAO）的被动转移。自身抗原类型和抗体类别影响。
Clin Exp Immunol. 1976 Dec;26(3):549-62.