Giacon Valeria, Sanduzzi Zamparelli Stefano, Sanduzzi Zamparelli Alessandro, Bruzzese Dario, Bocchino Marialuisa
Section of Respiratory Disease, Department of Clinical Medicine and Surgery, Monaldi Hospital, University Federico II of Naples.
Staff of United Nations Educational, Scientific and Cultural Organization (UNESCO), Health Education and Sustainable Development, University Federico II of Naples.
Multidiscip Respir Med. 2021 Dec 3;16(1):791. doi: 10.4081/mrm.2021.791. eCollection 2021 Jan 15.
Currently, the prognosis of bronchiectasis is based on different prognostic indicators, like BSI and FACED score, founded on clinical-demographic, functional and radiological criteria. Both scoring systems include the number of lobes involved in bronchiectasis, which represents an adverse prognostic index. Our study aimed to investigate the prognostic role of the clinical-functional parameters and the number of involved lobes ratio in adult bronchiectasis.
The study was conducted on 52 patients diagnosed with non-cystic fibrosis bronchiectasis (NCFB) between 2015 and 2017 who attended the Pneumology Unit of Monaldi Hospital in Naples, Italy. Correlations between clinical- functional parameters (BMI, smoking history, number of exacerbations in the previous year, spirometry, DL, ABG test, and 6MWT) and number of involved lobes were investigated.
At baseline, the number of exacerbations in the previous year had a statistically significant association with the number of involved lobes. Furthermore, at baseline, the radiological criterion was also negatively associated with some functional parameters (FEV/FVC ratio e FEF). Statistical significance was lost during the follow up, demonstrating the effectiveness of the therapy.
Imaging extension represents a promising biomarker of disease severity as well as a helpful follow up tool for non-Cystic Fibrosis bronchiectasis (NCFB).
目前，支气管扩张症的预后基于不同的预后指标，如基于临床人口统计学、功能和放射学标准建立的BSI和FACED评分。这两种评分系统都包括支气管扩张累及的肺叶数量，这是一个不良预后指标。我们的研究旨在调查临床功能参数和累及肺叶比例在成人支气管扩张症中的预后作用。
该研究对2015年至2017年间在意大利那不勒斯莫纳尔迪医院呼吸科就诊的52例诊断为非囊性纤维化支气管扩张症（NCFB）的患者进行。研究了临床功能参数（BMI、吸烟史、前一年的加重次数、肺功能测定、肺弥散功能、动脉血气分析和6分钟步行试验）与累及肺叶数量之间的相关性。
在基线时，前一年的加重次数与累及肺叶数量有统计学意义的关联。此外，在基线时，放射学标准也与一些功能参数（FEV/FVC比值和FEF）呈负相关。在随访期间这种统计学意义消失了，表明了治疗的有效性。
影像学范围是疾病严重程度的一个有前景的生物标志物，也是非囊性纤维化支气管扩张症（NCFB）有用的随访工具。
