Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Harbin Medical University, Harbin, Heilongjiang, China.
Medicine (Baltimore). 2023 Aug 25;102(34):e34870. doi: 10.1097/MD.0000000000034870.
In recent years, many studies have addressed cardiac aging and related diseases. This study aims to understand the research trend of cardiac aging and find new hot issues.
We searched the web of science core collection database for articles published between 2003 and 2022 on the topic of "cardiac aging." Complete information including keywords, publication year, journal title, country, organization, and author were extracted for analysis. The VOS viewer software was used to generate network maps of keywords, countries, institutions, and author relationships for visual network analysis.
A total of 1002 papers were analyzed in the study. Overall, the number of annual publications on cardiac aging has increased since 2009, and new hot topics are emerging. The top 3 countries with the most publications were the United States (471 articles), China (209 articles) and Italy (101 articles). The University of Washington published the most papers (35 articles). The cluster analysis with author as the keyword found that the connections among different scholars are scattered and clustered in a small range. Network analysis based on keyword co-occurrence and year of publication identified relevant features and trends in cardiac aging research. According to the results of cluster analysis, all the articles are divided into 4 topics: "mechanisms of cardiac aging", "prevention and treatment of cardiac aging", "characteristics of cardiac aging", and "others." In recent years, the mechanism and treatment of cardiac aging have attracted the most attention. In both studies, animal models are used more often than in human populations. Mitochondrial dysfunction, autophagy and mitochondrial autophagy are hotspots in current research.
In this study, bibliometric analysis was used to analyze the research trend of cardiac aging in the past 20 years. The mechanism and treatment of cardiac aging are the most concerned contents. Mitochondrial dysfunction, autophagy and mitophagy are the focus of future research on cardiac aging.
近年来，许多研究都涉及心脏衰老及其相关疾病。本研究旨在了解心脏衰老的研究趋势，并寻找新的热点问题。
我们在 Web of Science 核心合集数据库中检索了 2003 年至 2022 年期间关于“心脏衰老”主题的文章。提取了包括关键词、发表年份、期刊标题、国家、机构和作者在内的完整信息进行分析。使用 VOS viewer 软件生成关键词、国家、机构和作者关系的网络图，进行可视化网络分析。
本研究共分析了 1002 篇论文。总体而言，自 2009 年以来，每年关于心脏衰老的出版物数量都在增加，并且出现了新的热点。发表论文数量最多的前 3 个国家是美国（471 篇）、中国（209 篇）和意大利（101 篇）。华盛顿大学发表的论文最多（35 篇）。以作者为关键词的聚类分析发现，不同学者之间的联系分散且在小范围内聚集。基于关键词共现和发表年份的网络分析确定了心脏衰老研究的相关特征和趋势。根据聚类分析的结果，所有文章分为 4 个主题：“心脏衰老的机制”、“心脏衰老的预防和治疗”、“心脏衰老的特征”和“其他”。近年来，心脏衰老的机制和治疗最受关注。在这两项研究中，动物模型比人群更常用。线粒体功能障碍、自噬和线粒体自噬是当前研究的热点。
本研究采用文献计量学分析方法分析了过去 20 年心脏衰老的研究趋势。心脏衰老的机制和治疗是最受关注的内容。线粒体功能障碍、自噬和线粒体自噬是未来心脏衰老研究的重点。
