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6-溴靛红-3'-肟（6BIO）通过诱导自噬来防止心肌衰老。

6-Bromoindirubin-3'-oxime (6BIO) prevents myocardium from aging by inducing autophagy.

机构信息

Department of Geriatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China.

Division of Cardiology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

出版信息

Aging (Albany NY). 2020 Dec 26;12(24):26047-26062. doi: 10.18632/aging.202253.

DOI:10.18632/aging.202253
PMID:33401248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7803501/
Abstract

6-Bromoindirubin-3'-oxime (6BIO) is a novel small molecule that exerts positive effects on several age-related alterations. However, the anti-aging effects of 6BIO on the aging heart remain unknown. Herein, we aim to investigate the effects of 6BIO on the myocardium and its underlying mechanism and vitro. Following 6BIO treatment, an increased p53 contents, a reduced p16 and β-gal levels, and attenuation of cardiac fibrosis were observed, suggesting 6BIO retarded aging of cardiomyocytes. As observed, 6BIO reduced p62 contents, elevated the levels of Beclin-1 and the ratio of LC3II/I, indicating the induction of autophagy, while the reduction of the accumulation of ROS indicated 6BIO alleviated oxidative stress. In addition, 6BIO treatment inhibited both GSK3β signaling and mTOR signaling. 6BIO might be a promising agent for preventing myocardium from aging.

摘要

6-溴靛红-3'-肟（6BIO）是一种新型小分子，对多种与年龄相关的改变有积极作用。然而，6BIO 对衰老心脏的抗衰老作用尚不清楚。在此，我们旨在研究 6BIO 对心肌的作用及其潜在机制。体外实验结果表明，6BIO 处理后，p53 含量增加，p16 和 β-gal 水平降低，心肌纤维化减弱，提示 6BIO 延缓了心肌细胞衰老。结果表明，6BIO 降低了 p62 含量，增加了 Beclin-1 水平和 LC3II/I 的比值，表明自噬的诱导，而 ROS 积累的减少表明 6BIO 减轻了氧化应激。此外，6BIO 抑制了 GSK3β 信号和 mTOR 信号。6BIO 可能是一种有前途的预防心肌衰老的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b65/7803501/d0bd97a14e92/aging-12-202253-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b65/7803501/72b4a70d7790/aging-12-202253-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b65/7803501/d0bd97a14e92/aging-12-202253-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b65/7803501/65c61b7144e5/aging-12-202253-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b65/7803501/58c133b05143/aging-12-202253-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b65/7803501/48a8686211f6/aging-12-202253-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b65/7803501/a41237c44622/aging-12-202253-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b65/7803501/966cd58943da/aging-12-202253-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b65/7803501/72b4a70d7790/aging-12-202253-g009.jpg
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