Department of Pathology.
Galveston National Laboratory, The University of Texas Medical Branch, Galveston.
J Infect Dis. 2023 Nov 13;228(Suppl 7):S582-S586. doi: 10.1093/infdis/jiad377.
Inflammation and cytopenia are commonly observed during Ebola virus (EBOV) infection; however, mechanisms responsible for EBOV-induced cell death remain obscure. While apoptosis and necrosis are already identified as mechanisms of cell death induced by the virus, our study demonstrates that THP-1 monocytes and SupT1 T cells exposed to EBOV undergo pyroptosis and necroptosis, respectively, through a direct contact with EBOV, and also mediate pyroptosis or necroptosis of uninfected bystander cells via indirect effects associated with secreted soluble factors. These results emphasize novel aspects of interactions between EBOV and immune cell populations and provide a better understanding of the immunopathogenesis of EBOV disease.
在埃博拉病毒（EBOV）感染过程中，炎症和细胞减少症很常见；然而，导致 EBOV 诱导的细胞死亡的机制尚不清楚。虽然凋亡和坏死已被确定为病毒诱导的细胞死亡的机制，但我们的研究表明，与 EBOV 直接接触的 THP-1 单核细胞和 SupT1 T 细胞分别经历细胞焦亡和坏死，并且还通过与分泌的可溶性因子相关的间接作用介导未感染旁观者细胞的细胞焦亡或坏死。这些结果强调了 EBOV 和免疫细胞群体之间相互作用的新方面，并更好地理解了 EBOV 疾病的免疫发病机制。
