Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA.
Med Sci Monit. 2023 Sep 1;29:e942244. doi: 10.12659/MSM.942244.
A new variant of SARS-CoV-2 has currently achieved global domination. EG.5 (Eris) was first reported by the World Health Organization (WHO) on February 17, 2023, and designated as a variant under monitoring (VUM) on July 19, 2023. EG.5 (Eris), and its sublineages, EG.5.1, EG.5.1.1, and EG.5.2, is a descendent lineage of XBB.1.9.2, which has the same spike amino acid profile as XBB.1.5 (Kraken). However, EG.5 (Eris) has an additional F456L amino acid mutation in the spike protein compared to these parent subvariants, and the subvariant EG.5.1 has another spike mutation, Q52H. Following risk evaluation by the WHO, EG.5 (Eris) and its sublineages were designated as a variant of interest (VOI) on August 8, 2023. In the US, the Centers for Disease Control and Prevention (CDC) provides two-weekly monitoring data on the incidence and mortality from COVID-19 and SARS-CoV-2 variants. The most recent CDC data for August 19, 2023, showed an increase in cases in the past two weeks, with hospitalizations for COVID-19 increasing by 14.3% and mortality from COVID-19 rising by 8.3%. In the US, the most common COVID-19 cases have been due to three new SARS-CoV-2 Omicron variants: EG.5 (Eris) (20.6%); FL.1.5.1 (Fornax) (13.3%); and XBB.1.16 (Arcturus) (10.7%). This Editorial aims to highlight the importance of rapid virus genomic sequencing and continued global SARS-CoV-2 surveillance to identify rapidly emerging SARS-CoV-2 Omicron variants, such as EG.5 (Eris).
一种新的 SARS-CoV-2 变体目前已在全球范围内占据主导地位。例如，EG.5（Eris）于 2023 年 2 月 17 日首次由世界卫生组织（WHO）报告，并于 2023 年 7 月 19 日被指定为监测中的变体（VUM）。EG.5（Eris）及其亚系 EG.5.1、EG.5.1.1 和 EG.5.2，是 XBB.1.9.2 的后裔，其刺突氨基酸谱与 XBB.1.5（Kraken）相同。然而，与这些亲本亚变体相比，EG.5（Eris）的刺突蛋白中具有额外的 F456L 氨基酸突变，而亚变体 EG.5.1 则具有另一个刺突突变 Q52H。在经过世卫组织风险评估后，EG.5（Eris）及其亚系于 2023 年 8 月 8 日被指定为关注变体（VOI）。在美国，疾病控制与预防中心（CDC）提供有关 COVID-19 和 SARS-CoV-2 变体发病率和死亡率的两周监测数据。截至 2023 年 8 月 19 日的最新 CDC 数据显示，过去两周病例有所增加，COVID-19 住院人数增加了 14.3%，COVID-19 死亡率上升了 8.3%。在美国，最常见的 COVID-19 病例是由三种新的 SARS-CoV-2 奥密克戎变体引起的：EG.5（Eris）（20.6%）；FL.1.5.1（Fornax）（13.3%）；和 XBB.1.16（Arcturus）（10.7%）。本社论旨在强调快速进行病毒基因组测序和持续进行全球 SARS-CoV-2 监测的重要性，以识别快速出现的 SARS-CoV-2 奥密克戎变体，例如 EG.5（Eris）。
