Durga Pradeep Ganipineni Vijay, Ajmeera Rajunaik, Jha Rohit K, Medikonda Mallareddy, Saifuddin Rehan, Singh Faziljot
Department of Internal Medicine, King George Hospital, Visakhapatnam, Andhra Pradesh, India.
Department of ENT, Kakatiya Medical College, Warangal, Telangana, India.
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 1):S285-S287. doi: 10.4103/jpbs.jpbs_496_22. Epub 2023 Jul 5.
A complicated hypersensitive reaction to inhaled fungal antigens results in allergic bronchopulmonary aspergillosis (ABPA), an immunologic pulmonary disease. ABPA complicates nearly 2% of instances of persistent asthma as well as nearly 10% of chronic cases of steroid-dependent asthma, and it occurs most frequently in immunocompetent patients. The purpose of the current research was to analyze the radiological and clinical features of the participants as well as the serological association of ABPA.
From April 2020 to April 2021, a retrospective investigation was conducted. The study included patients based on the confirmation. Analysis was done on the demographic information and pathological and radiological test results of the patients. The patients' pre-bronchodilator and post-bronchodilator spirometry was compared, and asthmatic control was estimated.
A total of 50 patients were investigated at in this study. Demographic findings indicated young subjects and aa female predominance. Cough was the most prevalent symptom in 84% of patients. Asthma of the bronchi was a risk factor for all of the patients. The mean serum immunoglobulin E level and the mean absolute eosinophil count were 533 cells/L and 2269 UI/mL, respectively. Spirometry results from the study's participants indicated an obstructive pattern in about 80% of cases. The most typical radiological abnormality observed was bronchiectasis, followed by parenchymal opacities.
In conclusion, when treating asthma that is challenging to control, the diagnosis of ABPA must be taken into account. Delay in diagnosis might result in declining lung function, worsening asthma control, possibly irreversible alterations, greater treatment costs, and declined quality of life.
对吸入性真菌抗原的复杂超敏反应会导致变应性支气管肺曲霉病（ABPA），这是一种免疫性肺部疾病。ABPA使近2%的持续性哮喘病例以及近10%的激素依赖型哮喘慢性病例病情复杂化，且最常发生于免疫功能正常的患者。本研究的目的是分析参与者的放射学和临床特征以及ABPA的血清学关联。
2020年4月至2021年4月进行了一项回顾性调查。该研究纳入了经确诊的患者。对患者的人口统计学信息以及病理和放射学检查结果进行了分析。比较了患者支气管扩张剂使用前和使用后的肺量计测量结果，并评估了哮喘控制情况。
本研究共调查了50例患者。人口统计学结果显示患者以年轻人为主，女性居多。咳嗽是84%患者中最常见的症状。支气管哮喘是所有患者的一个危险因素。血清免疫球蛋白E平均水平和嗜酸性粒细胞绝对计数平均值分别为533个细胞/升和2269国际单位/毫升。该研究参与者的肺量计测量结果显示，约80%的病例呈现阻塞性模式。观察到的最典型放射学异常为支气管扩张，其次是实质浑浊。
总之，在治疗难以控制的哮喘时，必须考虑ABPA的诊断。诊断延迟可能导致肺功能下降、哮喘控制恶化、可能出现不可逆改变、治疗成本增加以及生活质量下降。
