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月球岩石大麻致一名20岁男性出现精神病性症状及新发癫痫发作

Moon Rock Cannabis-Induced Psychosis and New-Onset Seizures in a 20-Year-Old Male.

作者信息

Leczycki Martin, Zaki Peter, Espiridion Eduardo D

机构信息

Psychiatry, Reading Hospital - Tower Health, West Reading, USA.

Neurosurgery, Drexel University College of Medicine, Philadelphia, USA.

出版信息

Cureus. 2023 Jul 31;15(7):e42752. doi: 10.7759/cureus.42752. eCollection 2023 Jul.

DOI:10.7759/cureus.42752
PMID:37654922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10468007/
Abstract

"Moon rock" cannabis is a type of new and highly potent preparation of cannabis, which is made of a strain of cannabis dipped in hash oil and sprinkled with kief crystals, effectively increasing the concentration of δ-9-tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, well beyond what is naturally found in the cannabis plant. The use of increasingly potent forms of cannabis has far-reaching health implications, including psychiatric and neurologic effects, which are not yet fully understood. This case report summarizes existing knowledge of the association of cannabis use with psychosis and seizures and describes a novel case of "moon rock" cannabis-induced psychosis and new-onset seizures.

摘要

“月岩”大麻是一种新型的、效力极强的大麻制剂,它由一种大麻菌株浸渍在哈希油中并撒上大麻花粉晶体制成,能有效提高大麻中主要的精神活性化合物δ-9-四氢大麻酚(THC)的浓度,远远超过大麻植物中的天然含量。使用效力越来越强的大麻形式对健康有深远影响,包括精神和神经方面的影响,而这些影响尚未被完全了解。本病例报告总结了大麻使用与精神病和癫痫发作关联的现有知识,并描述了一例由“月岩”大麻引发的精神病和新发癫痫发作的新病例。

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本文引用的文献

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Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies.大麻二酚治疗难治性癫痫儿童和成人难治性癫痫发作的治疗和临床基础。
Exp Neurol. 2023 Jan;359:114237. doi: 10.1016/j.expneurol.2022.114237. Epub 2022 Oct 4.
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Chronic Synthetic Marijuana Use: A Case of First-Onset Seizures as a Withdrawal Symptom.长期使用合成大麻:首例以癫痫发作为戒断症状的病例。
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Protein Interactors and Trafficking Pathways That Regulate the Cannabinoid Type 1 Receptor (CB1R).调节1型大麻素受体(CB1R)的蛋白质相互作用分子及运输途径
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The Problem with the Current High Potency THC Marijuana from the Perspective of an Addiction Psychiatrist.从成瘾精神科医生的角度看当前高效力四氢大麻酚大麻的问题
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Synthetic Cannabinoids: Pharmacology, Behavioral Effects, and Abuse Potential.合成大麻素:药理学、行为效应及滥用潜力
Curr Addict Rep. 2014 Jun 1;1(2):129-136. doi: 10.1007/s40429-014-0014-y.
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