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长期使用合成大麻:首例以癫痫发作为戒断症状的病例。

Chronic Synthetic Marijuana Use: A Case of First-Onset Seizures as a Withdrawal Symptom.

作者信息

Edinoff Amber N, Doppalapudi Prithvi, Fort Juliana M

机构信息

Department of Psychiatry and Behavioral Medicine, Louisiana State University Health Shreveport.

出版信息

Health Psychol Res. 2022 Apr 26;10(3):34617. doi: 10.52965/001c.34617. eCollection 2022.

DOI:10.52965/001c.34617
PMID:35774900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9239357/
Abstract

A 44-year-old male with no known past medical history but a known history of daily synthetic marijuana use presented to the emergency department after two witnessed seizures. The patient was admitted to the neurology service, where he was worked up with an MRI with epilepsy protocol and an EEG. During admission, the patient was admitted to daily synthetic marijuana use. He did note that he had started to decrease the amount of mojo he used daily in an attempt to stop. His last use was at 9 am the day of his admission. He was trying to decrease his use; his girlfriend of difficulty word-finding noted periods. Synthetic marijuana (SM) or "mojo" use has been increasing in the past decade for two reasons; It is considered an herbal product and has been legal. A withdrawal syndrome of SM use has been characterized chiefly as tachycardia, irritation, anxiety, and mood swings. These withdrawal symptoms are usually seen with chronic use. Some early results in the literature also show that SM use can lead to functional and structural neuronal changes. This manuscript discusses a case of a first on-set seizure as a possible withdrawal symptom in chronic SM use.

摘要

一名44岁男性,既往无已知病史,但有每日吸食合成大麻的已知病史,在两次癫痫发作被目击后前往急诊科就诊。该患者被收入神经科,在那里接受了癫痫方案的MRI检查和脑电图检查。住院期间,患者承认每日吸食合成大麻。他确实提到,他已开始减少每日使用的“魔力”(合成大麻)量,试图戒掉。他最后一次使用是在入院当天上午9点。他正在努力减少使用量;他有找词困难的女友注意到了这一时期。在过去十年中,合成大麻(SM)或“魔力”的使用量一直在增加,原因有两个;它被认为是一种草药产品,并且是合法的。SM使用的戒断综合征主要表现为心动过速、易怒、焦虑和情绪波动。这些戒断症状通常在长期使用时出现。文献中的一些早期结果还表明,使用SM会导致神经元功能和结构的改变。本文讨论了一例首次发作的癫痫作为慢性SM使用中可能的戒断症状的病例。

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本文引用的文献

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Historical and Current Perspectives of Synthetic Marijuana: Critical Review.历史与现状视角下的合成大麻素:批判性回顾。
J Addict Nurs. 2020 Apr/Jun;31(2):85-91. doi: 10.1097/JAN.0000000000000333.
2
Comparison of the Neurotoxic and Seizure-Inducing Effects of Synthetic and Endogenous Cannabinoids with Δ-Tetrahydrocannabinol.合成大麻素和内源性大麻素与Δ-四氢大麻酚的神经毒性和致癫痫作用比较
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