Korosteleva T A, Mel'nikov R A, Belokhvostova A T, Movsesian K S, Skadova V M
Vopr Onkol. 1986;32(8):38-45.
3-hydroxyanthranilic acid(3-HAA)-antigen, commonly identifiable in blood serum of gastrointestinal cancer patients was shown to influence immunologic vigor in vitro. Treatment of patients' cultured lymphocytes with 3-HAA-antigen and PHA produced a statistically significant inhibition of blastogenic reaction of lymphocytes. Exposure to the said antigen gave a positive leukocyte migration inhibition test both in patients and controls. Antibodies against 3-HAA-antigen were identified in patients' serum by complement fixation test. Blood serum levels of the said antibodies and IgG were found to be in correlation with blood-3-HAA-antigen concentration. Patients' serum revealed an immunosuppressive activity inhibiting formation of antibody-producing cells to sheep erythrocytes in Jerne assay in mice.
3-羟基邻氨基苯甲酸（3-HAA）抗原常见于胃肠道癌症患者的血清中，已证明其在体外会影响免疫活力。用3-HAA抗原和PHA处理患者培养的淋巴细胞，对淋巴细胞的增殖反应产生了具有统计学意义的抑制作用。接触该抗原在患者和对照组中均产生了阳性白细胞迁移抑制试验结果。通过补体结合试验在患者血清中鉴定出了针对3-HAA抗原的抗体。发现该抗体和IgG的血清水平与血液中3-HAA抗原浓度相关。在小鼠的耶尔恩试验中，患者血清显示出抑制针对绵羊红细胞的抗体产生细胞形成的免疫抑制活性。
