Korosteleva T A, Pavlov K A, Mel'nikov R A, Saprin A N, Belokhvostova A T
Vopr Onkol. 1985;31(6):52-60.
The following parameters were studied in cases of gastrointestinal tumors: 3-hydroxyanthranilic acid (3-HAA)-antigen in blood serum; antibodies to 3-HAA-antigen; immunoglobulins G, A and M (after Manchini); 3-HAA-antigen effect on blastogenic reaction of lymphocytes; 3-HAA-antigen effect on leucocyte migration; blood serum effect on cells producing antibodies to ram erythrocytes, and levels of T-lymphocytes and their subpopulations. The studies were conducted before operation, 4-6, 7 and more months after operation. Tumor removal as well as tumor recurrences and metastases were shown to have an effect on the first 4 parameters. 3-HAA-antigen stimulated the formation of specific antibodies, suppressed blastogenic reaction of lymphocytes but failed to affect leucocyte migration significantly.
血清中的3 - 羟基邻氨基苯甲酸（3 - HAA）抗原；针对3 - HAA抗原的抗体；免疫球蛋白G、A和M（按照曼基尼法）；3 - HAA抗原对淋巴细胞增殖反应的影响；3 - HAA抗原对白细胞迁移的影响；血清对产生抗绵羊红细胞抗体的细胞的影响，以及T淋巴细胞及其亚群的水平。这些研究在手术前、手术后4 - 6个月、7个月及更长时间进行。结果显示，肿瘤切除以及肿瘤复发和转移对前4个参数有影响。3 - HAA抗原刺激特异性抗体的形成，抑制淋巴细胞的增殖反应，但对白细胞迁移没有显著影响。
