Yang Jun, Zhu Biyue, Ran Chongzhao
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown, Boston, Massachusetts 02129, United States.
Chem Biomed Imaging. 2023 Jul 7;1(5):434-447. doi: 10.1021/cbmi.3c00033. eCollection 2023 Aug 28.
The application of bio-orthogonality has greatly facilitated numerous aspects of biological studies in recent years. In particular, bio-orthogonal chemistry has transformed biological research, including in vitro conjugate chemistry, target identification, and biomedical imaging. In this review, we highlighted examples of bio-orthogonal in vivo imaging published in recent years. We grouped the references into two major categories: bio-orthogonal chemistry-related imaging and in vivo imaging with bio-orthogonal nonconjugated pairing. Lastly, we discussed the challenges and opportunities of bio-orthogonality for in vivo imaging.
近年来，生物正交性的应用极大地推动了生物学研究的诸多方面。特别是，生物正交化学已经改变了生物学研究，包括体外共轭化学、靶点识别和生物医学成像。在本综述中，我们重点介绍了近年来发表的生物正交体内成像的实例。我们将参考文献分为两大类：生物正交化学相关成像和生物正交非共轭配对的体内成像。最后，我们讨论了生物正交性在体内成像方面面临的挑战和机遇。
