Neurologia y Neuroimagen, Instituto Neurologico de Colombia (INDEC), Medellin, Antioquia, Colombia.
Spine & Brain Institute, Ascension St. Vincent's Riverside Hospital, Jacksonville, FL, 32204, USA.
F1000Res. 2023 Aug 1;10:1305. doi: 10.12688/f1000research.74506.2. eCollection 2021.
A clear understanding of the origin and role of the different subtypes of the B cell lineage involved in the activity or remission of multiple sclerosis (MS) is important for the treatment and follow-up of patients living with this disease. B cells, however, are dynamic and can play an anti-inflammatory or pro-inflammatory role, depending on their milieu. Depletion of B cells has been effective in controlling the progression of MS, but it can have adverse side effects. A better understanding of the role of the B cell subtypes, through the use of surface biomarkers of cellular activity with special attention to the function of memory and other regulatory B cells (Bregs), will be necessary in order to offer specific treatments without inducing undesirable effects.
清楚了解参与多发性硬化症（MS）活动或缓解的不同 B 细胞谱系亚型的起源和作用，对于患有这种疾病的患者的治疗和随访非常重要。然而，B 细胞是动态的，可以根据其环境发挥抗炎或促炎作用。B 细胞耗竭已被证明可有效控制 MS 的进展，但它可能会产生不良的副作用。为了提供无不良反应的特定治疗方法，有必要通过使用细胞活性的表面生物标志物，特别关注记忆 B 细胞和其他调节性 B 细胞（Bregs）的功能，更好地了解 B 细胞亚型的作用。
