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医疗保健中病原病毒和细菌的侧向流动检测

Lateral flow assay of pathogenic viruses and bacteria in healthcare.

机构信息

School of Materials Science and Engineering, Peking University; First Hospital Interdisciplinary Research Center, Peking University, Beijing 100871, P.R. China.

Peking University First Hospital; Peking University Institute of Nephrology, Beijing 100034, P. R. China.

出版信息

Analyst. 2023 Sep 25;148(19):4573-4590. doi: 10.1039/d3an00719g.

Abstract

Healthcare-associated pathogenic viruses and bacteria can have a serious impact on human health and have attracted widespread global attention. The lateral flow assay is a unidirectional detection based on the binding of a target analyte and a bioreceptor on the device lateral flow. With incredible advantages over traditional chromatographic methods, such as rapid detection, ease of manufacture and cost effectiveness, these test strips are increasingly considered the ideal form for point-of-care applications. This review explores lateral flow assays for pathogenic viruses and bacteria, with a particular focus on methodologies, device components, construction methods, and applications. We anticipate that this review could provide exciting opportunities for developing new lateral flow devices for pathogens and advance related healthcare applications.

摘要

与医疗保健相关的病原性病毒和细菌会对人类健康造成严重影响,这引起了全球的广泛关注。侧向流动分析是一种基于目标分析物与设备上的生物受体结合的单向检测方法。与传统的色谱方法相比,侧向流条具有令人难以置信的优势,如快速检测、易于制造和具有成本效益,这些测试条越来越被认为是即时护理应用的理想形式。本综述探讨了用于病原性病毒和细菌的侧向流动分析,特别关注方法学、器件组件、构建方法和应用。我们预计,这篇综述将为开发用于病原体的新型侧向流动器件并推进相关的医疗保健应用提供令人兴奋的机会。

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