Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
mBio. 2023 Oct 31;14(5):e0121223. doi: 10.1128/mbio.01212-23. Epub 2023 Sep 1.
Defining correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infection informs vaccine policy for booster doses and future vaccine designs. Existing studies demonstrate humoral correlates of protection, but the role of T cells in protection is still unclear. In this study, we explore antibody and T cell immune responses associated with protection against Delta variant vaccine breakthrough infection in a well-characterized cohort of UK Healthcare Workers (HCWs). We demonstrate evidence to support a role for CD4+ and CD8+ T cells as well as antibodies against Delta vaccine breakthrough infection. In addition, our results suggest a potential role for cross-reactive T cells in vaccine breakthrough.
定义针对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗突破性感染的保护相关因素，为加强针和未来疫苗设计提供疫苗政策信息。现有研究表明了体液保护相关因素，但 T 细胞在保护中的作用仍不清楚。在这项研究中，我们在一个特征明确的英国医疗保健工作者（HCW）队列中探索了与针对 Delta 变异株疫苗突破性感染的保护相关的抗体和 T 细胞免疫反应。我们证明了 CD4+和 CD8+T 细胞以及针对 Delta 疫苗突破性感染的抗体在其中发挥作用的证据。此外，我们的结果表明，交叉反应性 T 细胞在疫苗突破性感染中可能发挥作用。
