Winkler R, Klieber M
Wien Klin Wochenschr. 1986 Aug 8;98(15):490-5.
50 spa patients with established atherosclerosis were divided randomly into 2 therapeutic groups. In addition to the usual balneotherapeutic programme including exercise, one group (J) received a course of "iodine brine concentrate" to drink and the control group (Cl) received a similar course with isotonic NaCl. All patients were submitted to a strictly controlled low cholesterol diet. The following parameters were determined at the beginning and at the end of therapy: total serum cholesterol, HDL-cholesterol, triglycerides, fibrinogen, viscosity of whole blood and of plasma, microhaematocrit. Significant improvement was found in total cholesterol and triglycerides (decreases) and in the HDL proportion of total cholesterol (increase) in both groups. Fibrinogen was raised significantly only in the Cl-group and did not alter in the J-group. Plasma viscosity decreased only in the J-group, not in the controls. It is concluded that several haemorheological parameters relevant to atherosclerotic risk are favourably influenced in the direction of haemodilution by the complex balneotherapy used in our spa including diet and exercise. With the exception of additional positive effects on fibrinogen level and on plasma viscosity no other specific effects of the iodine brine were detectable.
50名已确诊动脉粥样硬化的温泉疗养患者被随机分为两个治疗组。除了包括运动在内的常规浴疗方案外,一组(J组)服用一个疗程的“浓缩碘盐水”,对照组(Cl组)服用一个疗程的等渗氯化钠。所有患者都严格遵循低胆固醇饮食。在治疗开始和结束时测定以下参数:总血清胆固醇、高密度脂蛋白胆固醇、甘油三酯、纤维蛋白原、全血和血浆粘度、微量血细胞比容。两组的总胆固醇和甘油三酯(降低)以及总胆固醇中高密度脂蛋白比例(升高)均有显著改善。纤维蛋白原仅在Cl组显著升高,在J组无变化。血浆粘度仅在J组降低,对照组未降低。得出的结论是,我们温泉疗养所采用的包括饮食和运动在内的综合浴疗朝着血液稀释的方向对一些与动脉粥样硬化风险相关的血液流变学参数产生了有利影响。除了对纤维蛋白原水平和血浆粘度有额外的积极作用外,未检测到碘盐水的其他特定作用。