Harms H K, Bertele-Harms R M
Wien Klin Wochenschr. 1986 Aug 29;98(16):527-30.
Ulcerative colitis occurs before the age of 15 years in 20% and before 20 years in 40% of all patients involved. The frequency of this disease in patients at the University Children's Hospital of Munich has clearly risen over the past years. In many patients we found characteristic differences in history, clinical picture and laboratory results as compared with Crohn's disease. The most important diagnostic procedure is endoscopy of the entire colon. The histological examination of the biopsies taken during colonoscopy differentiated less clearly between these two entities than the macroscopic judgement by the endoscopist. The development of carcinoma must be considered even in children when the disease has lasted for seven years or longer. Ulcerative colitis must be differentiated from infectious diseases of the bowel by direct search for the relevant microorganisms and by serological testing.
20%的溃疡性结肠炎患者在15岁之前发病，40%的患者在20岁之前发病。在过去几年中，慕尼黑大学儿童医院患者中这种疾病的发病率明显上升。与克罗恩病相比，我们发现许多患者在病史、临床表现和实验室检查结果方面存在特征性差异。最重要的诊断方法是全结肠内镜检查。结肠镜检查时所取活检组织的组织学检查在区分这两种疾病方面不如内镜医师的肉眼判断清晰。即使在儿童患者中，当疾病持续7年或更长时间时，也必须考虑癌变的发生。必须通过直接查找相关微生物和血清学检测将溃疡性结肠炎与肠道传染病区分开来。
