Department of Cardiovascular Medicine, The Eighth Hospital of Wuhan, Wuhan City, Hubei Province, China.
Department of Surgery, The Eighth Hospital of Wuhan, Wuhan City, Hubei Province, China.
J Int Med Res. 2023 Aug;51(8):3000605231194457. doi: 10.1177/03000605231194457.
To reveal the significance of plasma galectin-3 and soluble CD40 ligand (sCD40L) levels in patients with ischemic cardiomyopathy (ICM) combined with atrial fibrillation.
In this case-control study, the case group comprised 60 patients with ICM combined with atrial fibrillation and the control group comprised patients with ICM without atrial fibrillation. Plasma galectin-3 and sCD40L levels, left atrial diameter (LAD), left ventricular ejection fraction (LVEF), and left ventricular diameter (LVD) were compared.
The plasma galectin-3 and sCD40L levels, LAD, and LVD were higher and the LVEF was lower in the case than control group. In the case group, the plasma galectin-3 and sCD40L levels were positively correlated with the LAD and LVD but negatively correlated with the LVEF. The area under the receiver operating characteristic curve of the plasma galectin-3 and sCD40L levels in the diagnosis of ICM combined with atrial fibrillation was 0.857 (95% confidence interval, 0.792-0.923) and 0.724 (95% confidence interval, 0.634-0.814), respectively.
The plasma galectin-3 and sCD40L levels are significantly elevated in patients with ICM combined with atrial fibrillation. Although both may have predictive value in the diagnosis of ICM combined with atrial fibrillation, galectin-3 may have the higher predictive value.
揭示血浆半乳糖凝集素-3 和可溶性 CD40 配体（sCD40L）水平在缺血性心肌病（ICM）合并心房颤动患者中的意义。
在这项病例对照研究中，病例组包括 60 例 ICM 合并心房颤动患者，对照组包括 ICM 无心房颤动患者。比较血浆半乳糖凝集素-3 和 sCD40L 水平、左心房直径（LAD）、左心室射血分数（LVEF）和左心室直径（LVD）。
与对照组相比，病例组的血浆半乳糖凝集素-3 和 sCD40L 水平、LAD 和 LVD 更高，LVEF 更低。在病例组中，血浆半乳糖凝集素-3 和 sCD40L 水平与 LAD 和 LVD 呈正相关，与 LVEF 呈负相关。血浆半乳糖凝集素-3 和 sCD40L 水平诊断 ICM 合并心房颤动的受试者工作特征曲线下面积分别为 0.857（95%置信区间，0.792-0.923）和 0.724（95%置信区间，0.634-0.814）。
ICM 合并心房颤动患者的血浆半乳糖凝集素-3 和 sCD40L 水平显著升高。虽然两者在诊断 ICM 合并心房颤动中均具有预测价值，但半乳糖凝集素-3 的预测价值可能更高。
