Department of Psychiatry, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Department of Psychiatry, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Psychiatry Res. 2023 Oct;328:115452. doi: 10.1016/j.psychres.2023.115452. Epub 2023 Aug 28.
Our meta-analysis demonstrated that intermittent theta burst stimulation (iTBS)/bilateral-TBS (Bi-TBS) and high-frequency repetitive transcranial magnetic stimulation (HF-rTMS)/bilateral-rTMS (Bi-rTMS) had similar efficacy, acceptability, and safety profiles for antidepressant treatment-resistant major depressive disorder (AD-TRD). In our sensitivity analysis that excluded a study that compared Bi-TBS with Bi-rTMS for older adults, all efficacy outcomes were also comparable between iTBS and HF-rTMS. Because iTBS does not require higher stimulation intensity and a longer stimulus time than conventional HF-rTMS protocols, we speculated that for those with AD-TRD, iTBS/Bi-TBS is a more helpful therapeutic modality in clinical practice than HF-rTMS/Bi-rTMS.
我们的荟萃分析表明，间歇性 theta 爆发刺激（iTBS）/双侧-TBS（Bi-TBS）和高频重复经颅磁刺激（HF-rTMS）/双侧-rTMS（Bi-rTMS）在治疗抗抑郁药难治性重度抑郁症（AD-TRD）方面具有相似的疗效、可接受性和安全性。在我们的敏感性分析中，排除了一项比较 Bi-TBS 与 Bi-rTMS 用于老年人的研究后，iTBS 和 HF-rTMS 之间的所有疗效结果也具有可比性。由于 iTBS 不需要比传统的 HF-rTMS 方案更高的刺激强度和更长的刺激时间，我们推测对于那些患有 AD-TRD 的人来说，iTBS/Bi-TBS 在临床实践中是一种比 HF-rTMS/Bi-rTMS 更有帮助的治疗方式。
