Lu Junyue, Huang Jiahao, Ye Anqi, Xie Chen, Bu Pan, Kang Jiliang, Hu Jiaxuan, Wen Youliang, Huang Haoyuan
School of Rehabilitation Medicine, Gannan Medical University, Ganzhou, China.
Third Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Front Neurol. 2024 Oct 11;15:1450435. doi: 10.3389/fneur.2024.1450435. eCollection 2024.
Stroke is a serious health issue that affects individuals, families, and society. Particularly, the upper limb dysfunction caused by stroke significantly reduces the quality of life for patients and may lead to psychological issues. Current treatment modalities are not fully effective in helping patients regain upper limb motor function to optimal levels. Therefore, there is an urgent need to explore new rehabilitation methods to address this issue.
The purpose of this meta-analysis and systematic review is to explore the effects of intermittent theta burst stimulation (iTBS) on upper limb function in stroke patients.
We searched PubMed, Cochrane Library, Embase, Web of Science, PEDro and China National Knowledge Internet as of April 8, 2024. Retrieved a total of 100 articles. Standardized mean differences (SMDs) and 95% confidence intervals (CI) were calculated.
The study included a total of 9 trials and involved 224 patients. The results demonstrate that compared to the control group, iTBS therapy significantly improved Fugl-Meyer assessment-upper extremity (FMA-UE) scores (SMD = 0.88; 95% CI = 0.11-1.66; = 0.03, = 84%), Action Research Arm Test (ARAT) scores (SMD = 0.83; 95% CI = 0.16-1.50; = 0.02, = 57%), and Barthel Index (BI) scores (SMD = 0.93; 95% CI = 0.53-1.32; < 0.0001, = 0%) in stroke patients.
The comprehensive evidence suggests that iTBS has superior effects in improving upper limb function and activities of daily living in stroke patients.
中风是一个严重的健康问题，影响着个人、家庭和社会。特别是，中风引起的上肢功能障碍显著降低了患者的生活质量，并可能导致心理问题。目前的治疗方式在帮助患者将上肢运动功能恢复到最佳水平方面并不完全有效。因此，迫切需要探索新的康复方法来解决这一问题。
本荟萃分析和系统评价的目的是探讨间歇性θ波爆发刺激（iTBS）对中风患者上肢功能的影响。
我们检索了截至2024年4月8日的PubMed、Cochrane图书馆、Embase、科学网、PEDro和中国知网。共检索到100篇文章。计算标准化平均差（SMD）和95%置信区间（CI）。
该研究共纳入9项试验，涉及224例患者。结果表明，与对照组相比，iTBS治疗显著提高了中风患者的Fugl-Meyer评估上肢（FMA-UE）评分（SMD = 0.88；95% CI = 0.11 - 1.66；P = 0.03，I² = 84%）、动作研究臂测试（ARAT）评分（SMD = 0.83；95% CI = 0.16 - 1.50；P = 0.02，I² = 57%）和Barthel指数（BI）评分（SMD = 0.93；95% CI = 0.53 - 1.32；P < 0.0001，I² = 0%）。
综合证据表明，iTBS在改善中风患者上肢功能和日常生活活动方面具有显著效果。
