Künnert B
Z Gesamte Inn Med. 1986 Jul 15;41(14):394-9.
The processes of normal lipid metabolism in peripheral cells are regulated predominantly by LDL receptors (supply of the cells with cholesterol and essential fatty acids). Conceptions about foam cell formation in arteriosclerosis, derived from findings in cell cultures, are discussed (modified LDL lipid peroxides etc.). In prevention and regression of arteriosclerosis intracellular hydrolysis of cholesterol esters and the removal of cholesterol from the cells and the vessel wall by HDL play an important role. Further, the content of polyunsaturated fatty acids in cholesterol esters and phospholipids seems to influence the largeness of arterial lipid depositions. The manifold functions of the phospholipids within the vessel wall and the blood plasma involved in prevention and regression of arteriosclerosis (including the effect of phosphatidylcholine liposomes) are reviewed.
外周细胞中正常脂质代谢过程主要由低密度脂蛋白受体调节（为细胞提供胆固醇和必需脂肪酸）。文中讨论了基于细胞培养结果得出的动脉粥样硬化中泡沫细胞形成的概念（修饰的低密度脂蛋白脂质过氧化物等）。在动脉粥样硬化的预防和逆转中，胆固醇酯的细胞内水解以及高密度脂蛋白将胆固醇从细胞和血管壁中清除起着重要作用。此外，胆固醇酯和磷脂中多不饱和脂肪酸的含量似乎会影响动脉脂质沉积的大小。本文综述了血管壁和血浆中磷脂在动脉粥样硬化预防和逆转中的多种功能（包括磷脂酰胆碱脂质体的作用）。
