Kuhfahl E
Z Gesamte Inn Med. 1986 Aug 1;41(15):409-13.
With regard to the clinically relevant pathogenetic significance of hyperlipacidaemias a survey of the metabolism of the free fatty acids in the intravascular space is given. The transport of the free fatty acids by albumin and lipoproteins is demonstrated and the importance of the non-protein-bound fraction of the free fatty acids is emphasized. The dynamics of the metabolism of the free fatty acids is characterized with the help of the fractional and absolute turnover rate. Furthermore, the author deals with the participation of individual organs in the total metabolism and the metabolic fate of the free fatty acids as well as with the sources of this lipid fraction. Finally the regulation of the plasma concentration of the free fatty acids and its significance for the maintenance of the caloric homoeostasis is described.
关于高脂血症的临床相关致病意义，本文对血管内空间游离脂肪酸的代谢进行了综述。阐述了白蛋白和脂蛋白对游离脂肪酸的转运，并强调了游离脂肪酸非蛋白结合部分的重要性。借助分数周转率和绝对周转率对游离脂肪酸代谢的动力学进行了表征。此外，作者还探讨了各个器官在游离脂肪酸总代谢中的参与情况、游离脂肪酸的代谢归宿以及该脂质部分的来源。最后描述了游离脂肪酸血浆浓度的调节及其对维持热量稳态的意义。
