College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 26 Hexing Road, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
Aulin College, Northeast Forestry University, 26 Hexing Road, Harbin 150040, Heilongjiang, China.
Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126628. doi: 10.1016/j.ijbiomac.2023.126628. Epub 2023 Aug 30.
Recently, using oxidized regenerated cellulose (ORC) to build a hydrogel system on promoting healing in wounds has a fast-growing market. However, it remains a challenge to improve the degree of oxidation of regenerated cellulose (RC) and to prepare matrices that are uniquely responsive to the wound environment. Herein, highly oxidized aldehyde-based cellulose from porous RC was prepared by NaBH-HCl swelling and then NaIO oxidation pathway. Chitosan (CS), ethylenediamine-cyclodextrin (EDA-CD) along with ORC have been used to construct hydrogel matrices that are pH-responsive and capable of controlled drug release for use as future wound dressings. And zinc oxide nanoparticles (ZnO NPs) with antimicrobial effect and ibuprofen (IBU) with analgesic effect were piggybacked into the hydrogel system. XRD was used to study the presence of ZnO. SEM was used to observe the surface structure of the prepared hydrogel. TEM was used to observe the particle size of the ZnO NPs. Meanwhile, the oxidation conditions of the ORC were explored. Furthermore, the mechanical, swelling, water retention, cytotoxicity, bacterial inhibition properties and treatment effect, which are closely related to the application of wound dressing, were carefully researched. The unique characteristics of prepared hydrogel, including pH-responsive degradability and sustained release properties of IBU, were also investigated.
最近，使用氧化再生纤维素（ORC）构建水凝胶系统以促进伤口愈合具有快速增长的市场。然而，提高再生纤维素（RC）的氧化程度并制备对伤口环境具有独特响应的基质仍然是一个挑战。在此，通过 NaBH-HCl 溶胀和 NaIO 氧化途径，从多孔 RC 制备了高度氧化的醛基纤维素。壳聚糖（CS）、乙二胺-环糊精（EDA-CD）与 ORC 一起用于构建 pH 响应的水凝胶基质，能够控制药物释放，用作未来的伤口敷料。具有抗菌作用的氧化锌纳米粒子（ZnO NPs）和具有镇痛作用的布洛芬（IBU）被负载到水凝胶系统中。XRD 用于研究 ZnO 的存在。SEM 用于观察制备的水凝胶的表面结构。TEM 用于观察 ZnO NPs 的粒径。同时，还探索了 ORC 的氧化条件。此外，还仔细研究了与伤口敷料应用密切相关的机械性能、溶胀性、保水性、细胞毒性、抑菌性能和治疗效果。还研究了制备的水凝胶的独特特性，包括 pH 响应的可降解性和 IBU 的持续释放特性。
