[Dynamics of the reactivity of cortical neurons to repeated electrophoretic application of acetylcholine].

Dynamics of reactivity was studied in 50 neurones of the rat sensorimotor cortex to repeated acetylcholine microiontophoresis. By the parameter of response plasticity the neurones are distributed into three groups--unchanging, decreasing and increasing the excitatory component of the reaction. A connection has been established of the type and rate of tonic and evoked activities dynamics with the duration of the excitatory component of neuronal reactions to acetylcholine. The highest probability of these dynamic activity changes manifestation is observed in cholinoceptive neurones with duration of excitatory reaction components to acetylcholine equal to 3.2, 8.1 and 13.5 s.