Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Heilongjiang 150006, China.
Bioorg Chem. 2023 Nov;140:106810. doi: 10.1016/j.bioorg.2023.106810. Epub 2023 Aug 25.
(-)-Cannabidiol is a class of non-psychoactive plant cannabinoids derived from cannabis plants. Currently, Epidiolex (Cannabidiol) has been approved by the FDA for the treatment of two rare and severe forms of epilepsy related diseases, namely Lennox-Gastaut syndrome (LGS) and Dravet (DS). In addition, Cannabidiol and its structural analogues have received increasing attention due to their potential therapeutic effects such as neuroprotection, anti-epilepsy, anti-inflammation, anti-anxiety, and anti-cancer. Based on literature review, no comprehensive reviews on the synthesis of Cannabidiol and its derivatives have been found in recent years. Therefore, this article summarizes the published synthesis methods of Cannabidiol and the synthesis routes of Cannabidiol derivatives, and introduces the biological activities of some Cannabidiol analogues that have been studied extensively and have significant activities.
(-)-大麻二酚是一种非精神活性植物大麻素，来源于大麻植物。目前，Epidiolex（大麻二酚）已获得 FDA 批准，用于治疗两种罕见且严重的与癫痫相关的疾病，即 Lennox-Gastaut 综合征（LGS）和 Dravet（DS）。此外，由于大麻二酚及其结构类似物具有神经保护、抗癫痫、抗炎、抗焦虑和抗癌等潜在治疗作用，因此受到越来越多的关注。根据文献综述，近年来尚未发现关于大麻二酚及其衍生物合成的综合评述。因此，本文总结了已发表的大麻二酚及其衍生物的合成方法，并介绍了一些已被广泛研究且具有显著活性的大麻二酚类似物的生物活性。
