Department of Physical Therapy for Cardiovascular and Respiratory Disorders, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
Department of Physical Therapy for Cardiovascular and Respiratory Disorders, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
Complement Ther Clin Pract. 2023 Nov;53:101795. doi: 10.1016/j.ctcp.2023.101795. Epub 2023 Aug 22.
This study aimed to compare the effects of aerobic, resistance, and combined exercises on thyroid function, lipid profile, exercise capacity, and quality of life (QoL) in hypothyroid women.
Sixty women aged 35 to 45 with clinical hypothyroidism were randomized to four equal groups: aerobic training (AT), resistance training (RT), combined AT/RT, and control groups. All exercises were performed at low to moderate intensity, three days per week, and for 12 weeks. Patients in all groups were on levothyroxine therapy. Outcome measures were free thyroxin (T4), thyroid stimulating hormone (TSH), lipid profile, estimated maximal oxygen consumption (VO max) and QoL assessed by the 12-item Short Form (SF-12) Health Survey.
All exercise groups showed significant improvements in all outcome measures compared to the baseline and the controls (p < 0.05). The combined AT/RT group showed more significant improvements in TSH and the mental component summary score of the SF-12 compared to the AT and RT groups (p < 0.05). The AT group showed the most significant improvement in estimated VO max, followed by the combined AT/RT and then the RT group. Non-significant differences were found between exercise groups in T4, blood lipids, and the physical component summary score of the SF-12 (p > 0.05).
In women with hypothyroidism on levothyroxine treatment, all AT, RT, and combined AT/RT could equally improve T4 levels, lipid profile, and physical health-related QoL. However, the combined AT/RT could induce the greatest improvements in TSH and mental health-related QoL, while the AT could have the greatest impact on exercise capacity in these patients.
Pan African Clinical Trial Registry (PACTR), retrospective, PACTR202305810673587.
本研究旨在比较有氧运动、抗阻运动和联合运动对甲状腺功能、血脂谱、运动能力和生活质量（QoL）的影响，研究对象为患有临床甲状腺功能减退的女性。
将 60 名年龄在 35 岁至 45 岁之间的患有临床甲状腺功能减退的女性患者随机分为四组：有氧运动训练（AT）组、抗阻运动训练（RT）组、联合 AT/RT 组和对照组。所有运动均以低至中等强度进行，每周 3 天，持续 12 周。所有患者均接受左甲状腺素治疗。评估指标包括游离甲状腺素（T4）、促甲状腺激素（TSH）、血脂谱、最大摄氧量（VO max）和 12 项简明健康状况调查问卷（SF-12）评估的生活质量。
与基线和对照组相比，所有运动组的所有评估指标均显著改善（p<0.05）。与 AT 组和 RT 组相比，联合 AT/RT 组的 TSH 和 SF-12 心理成分综合评分改善更显著（p<0.05）。AT 组的 VO max 估计值改善最显著，其次是联合 AT/RT 组，然后是 RT 组。各组之间 T4、血脂和 SF-12 身体成分综合评分无显著差异（p>0.05）。
在接受左甲状腺素治疗的甲状腺功能减退女性中，所有 AT、RT 和联合 AT/RT 均可同等改善 T4 水平、血脂谱和与身体健康相关的生活质量。然而，联合 AT/RT 可引起 TSH 和心理健康相关生活质量的最大改善，而 AT 对这些患者的运动能力影响最大。
泛非临床研究注册中心（PACTR），回顾性，PACTR202305810673587。
