First Department of Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, China.
Department of Emergency, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, China.
Biomed Pharmacother. 2023 Oct;166:115418. doi: 10.1016/j.biopha.2023.115418. Epub 2023 Sep 4.
Histone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family that plays an important role in the regulation of gene expression and protein function. In recent years, research on the role of HDAC11 in tumors has attracted increasing attention. This review summarizes the current knowledge on the subcellular localization, structure, expression, and functions of HDAC11 in tumors, as well as the regulatory mechanisms involved in its network, including ncRNA and substrates. Moreover, we focus on the progress made in targeting HDAC11 to overcome tumor therapy resistance, and the development of HDAC11 inhibitors for cancer treatment. Collectively, this review provides comprehensive insights into the potential clinical implications of HDAC11 for cancer therapy.
组蛋白去乙酰化酶 11（HDAC11）是组蛋白去乙酰化酶家族中的一个独特成员，在基因表达和蛋白质功能的调控中发挥着重要作用。近年来，HDAC11 在肿瘤中的作用研究引起了越来越多的关注。本文综述了 HDAC11 在肿瘤中的亚细胞定位、结构、表达和功能，以及其网络调控机制，包括 ncRNA 和底物。此外，我们还重点介绍了靶向 HDAC11 以克服肿瘤治疗耐药性的研究进展，以及用于癌症治疗的 HDAC11 抑制剂的开发。综上所述，本文全面探讨了 HDAC11 在癌症治疗中的潜在临床意义。
