Department of Medicine, Medical College, Pusan National University, Yangsan, Republic of Korea.
Department of Psychiatry, Pusan National University School of Medicine, Pusan National University, Busan, Republic of Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Psychiatry Res Neuroimaging. 2023 Oct;335:111705. doi: 10.1016/j.pscychresns.2023.111705. Epub 2023 Aug 22.
We investigate the role of neuropsychological tests, including the learning potential, in predicting amyloid-beta positron emission tomography (Aβ-PET) status in amnestic mild cognitive impairment (aMCI). This cross-sectional study included 64 patients with aMCI (31 Aβ-PET (-) and 33 (+)) who visited a memory impairment clinic at Pusan National University Hospital between 2014 and 2019. Patients underwent Aβ-PET scans using 18F-florbetaben and the Seoul Neuropsychological Screening Battery. Learning potential was determined based on the difference in scores between the first and third trials of the Seoul Verbal Learning test (SVLT). Binary logistic regression was used to demonstrate the association between Aβ-PET status and cognitive tests. Predictive ability of cognitive tests for Aβ deposition was investigated using receiver operating characteristic curves analysis. From logistic regression models, the SVLT learning potential and Rey-Osterrieth Complex Figure Test (RCFT) delayed recall were found to predict Aβ-PET positivity. The areas under the curve (AUC) of the SVLT learning potential and RCFT delayed recall were significantly different from 0.5. Our findings of an association between Aβ deposition status and learning potential and visuospatial memory suggest that these cognitive tests could be used to screen patients with aMCI for Aβ deposition status.
我们研究了神经心理学测试（包括学习潜能）在预测遗忘型轻度认知障碍（aMCI）患者淀粉样蛋白-β正电子发射断层扫描（Aβ-PET）状态中的作用。这项横断面研究纳入了 2014 年至 2019 年间在釜山国立大学医院记忆障碍门诊就诊的 64 名 aMCI 患者（31 名 Aβ-PET（-）和 33 名 Aβ-PET（+））。患者接受了 18F-氟比他滨和首尔神经心理筛选测验（SVLT）的 Aβ-PET 扫描。学习潜能基于 SVLT 第一和第三试验得分之间的差异来确定。二元逻辑回归用于显示 Aβ-PET 状态与认知测试之间的关联。使用受试者工作特征曲线分析研究认知测试对 Aβ 沉积的预测能力。从逻辑回归模型中发现，SVLT 学习潜能和 Rey-Osterrieth 复杂图形测试（RCFT）延迟回忆可预测 Aβ-PET 阳性。SVLT 学习潜能和 RCFT 延迟回忆的曲线下面积（AUC）显著不同于 0.5。我们发现 Aβ 沉积状态与学习潜能和视觉空间记忆之间存在关联，这表明这些认知测试可用于筛查 Aβ 沉积状态的 aMCI 患者。
