Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Sci Total Environ. 2023 Dec 15;904:166744. doi: 10.1016/j.scitotenv.2023.166744. Epub 2023 Sep 1.
Little is known about the associations of exposure to fine particulate matter (PM) and its constituents with ovarian reserve, and the potential susceptible window of exposure remains unclear.
We performed a retrospective cohort study of 5189 women who attended a fertility center in Hubei, China, during 2019-2022, and estimated concentrations of PM and its major constituents during the development of follicles (4th-6th month [W1], 0-4th month [W2], 0-6th month [W3]) and 1-year before measurement (W4) based on Tracking Air Pollution in China database. We used multivariable linear regression and logistic regression models to examine the associations of PM and its constituent exposures with anti-Müllerian hormone (AMH), the preferred indicator of ovarian reserve.
We observed significantly decreased AMH levels associated with increasing PM concentrations, with the percent changes (95 % confidence intervals [CIs]) of 1.99 % (0.24 %-3.71 %) during W1 and 3.99 % (0.74 %-7.15 %) during W4 for per 10 μg/m increases in PM.When PM exposure levels were equal to 50th percentile (32.6-42.3 μg/m) or more, monotonically decreased AMH levels and increased risks of low AMH were seen with increasing PM concentrations during W1 and W4 (P < 0.05). Black carbon (BC), ammonium (NH), nitrate (NO), and organic matter (OM) during W1, and NH, NO, as well as sulfate (SO) during W4 were significantly associated with decreased AMH. Moreover, PM and SO exposures during W4 were positively associated with low AMH. Additionally, the associations were stronger among women aged <35 years, lived in urban regions, or measured AMH in cold-season (P for interaction <0.05).
PM and specific chemical components (particularly NH, NO3, and SO4) exposure during the secondary to antral follicle stage and 1-year before measurement were associated with diminished ovarian reserve (DOR), indicating the adverse impact of PM and its constituent exposures on female reproductive potential.
人们对细颗粒物 (PM) 及其成分暴露与卵巢储备之间的关联知之甚少，潜在的易感暴露窗口仍不清楚。
我们对 2019 年至 2022 年期间在中国湖北一家生育中心就诊的 5189 名女性进行了回顾性队列研究，并根据中国大气污染物追踪数据库，估计了卵泡发育过程中（第 4-6 个月[W1]、0-4 个月[W2]、0-6 个月[W3]）和测量前 1 年（W4）的 PM 及其主要成分的浓度。我们使用多变量线性回归和逻辑回归模型来研究 PM 和其成分暴露与抗苗勒管激素（AMH）的关联，AMH 是卵巢储备的首选指标。
我们观察到 AMH 水平与 PM 浓度呈负相关，随着 PM 浓度的增加，W1 期间的百分比变化（95%置信区间[CI]）为 1.99%（0.24%-3.71%），W4 期间为 3.99%（0.74%-7.15%）。当 PM 暴露水平等于第 50 百分位数（32.6-42.3μg/m）或更高时，在 W1 和 W4 期间，随着 PM 浓度的增加，AMH 水平呈单调下降趋势，低 AMH 的风险增加（P<0.05）。W1 期间的黑碳 (BC)、铵 (NH)、硝酸盐 (NO) 和有机物 (OM)，以及 W4 期间的 NH、NO 和硫酸盐 (SO) 与 AMH 水平降低显著相关。此外，W4 期间的 PM 和 SO 暴露与低 AMH 呈正相关。此外，在年龄<35 岁、居住在城区或在冷季测量 AMH 的女性中，这种关联更强（P 交互<0.05）。
次级至窦前卵泡期和测量前 1 年的 PM 及其特定化学成分（尤其是 NH、NO3 和 SO4）暴露与卵巢储备减少（DOR）有关，表明 PM 及其成分暴露对女性生殖潜能有不利影响。
