Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, Ciudad de México, Mexico.
Departamento de Patología, Hospital General Dra Matilde Petra Montoya Lafragua, ISSSTE, Ciudad de México, Mexico.
World J Urol. 2023 Oct;41(10):2793-2799. doi: 10.1007/s00345-023-04558-x. Epub 2023 Sep 2.
Evaluate the therapeutic effect of a tomato lipidic extract (STE) in combination with selenium (Se) on rats with prostatic hyperplasia (PH) and to observe its possible mechanisms of action and synergism versus finasteride.
54 male Wistar rats of nine weeks old were divided in Control (C), PH, Finasteride (F), STE, Se, F + STE, F + Se, STE + Se and F + STE + Se with testosterone enanthate (except C). After 4 weeks of treatment administration, prostate weight, bladder weight, diuresis, prooxidant and antioxidant activity, dihydrotestosterone (DHT), androgen receptor (AR) expression and anatomopathological analysis were determined.
STE + Se decreased prostate weight 53.8% versus 28% in F group, also STE + Se decreased significatively glandular hyperplasia, prooxidant activity, DHT and AR expression and increased diuresis and antioxidant activity versus finasteride which increased MDA in prostate.
These results demonstrate a greater therapeutic and beneficial effect of tomato lipidic extract in combination with Se in young rats with PH with respect to finasteride without increase prooxidant activity.
评估番茄脂质提取物（STE）与硒（Se）联合治疗前列腺增生（PH）大鼠的疗效，并观察其与非那雄胺的可能作用机制和协同作用。
将 54 只 9 周龄雄性 Wistar 大鼠分为对照组（C）、PH 组、非那雄胺（F）组、STE 组、Se 组、F+STE 组、F+Se 组、STE+Se 组和 F+STE+Se 组（除 C 组外，用庚酸睾酮处理）。治疗 4 周后，测定前列腺重量、膀胱重量、尿量、氧化应激和抗氧化活性、二氢睾酮（DHT）、雄激素受体（AR）表达及解剖病理学分析。
STE+Se 组前列腺重量较 F 组降低 53.8%，而降低 28%；STE+Se 组还显著降低了腺体增生、氧化应激活性、DHT 和 AR 表达，增加了尿量，提高了抗氧化活性，而非那雄胺则增加了前列腺中的 MDA。
这些结果表明，与非那雄胺相比，番茄脂质提取物联合 Se 对年轻 PH 大鼠具有更大的治疗和有益作用，且不会增加氧化应激活性。
