Luis Heriberto Vázquez Mendoza, Patrick Mailloux Salinas, Elihu Campos Pérez, Bravo Guadalupe, Julian Arias Chávez David
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, México.
Departamento de Patología, Hospital General Dra. Matilde Petra Montoya Lafragua, ISSSTE, México.
Andrology. 2025 May;13(4):955-967. doi: 10.1111/andr.13736. Epub 2024 Aug 27.
Obesity represents a risk in the development of metabolic and oxidative stress (OS), as well as in male infertility. There is still no pharmacological treatment for obesity-induced male infertility, but the use of natural antioxidants has been proposed as a treatment.
The aim of this work is to evaluate the effect of a whole tomato lipid extract on rats that decreased their fertility and spermatogenesis after being induced obese with a high carbohydrate diet.
One hundred fourteen male Wistar rats of 12 weeks of age were used. Two groups were randomly formed non-obese control group (C, n = 54) and obese group (Ob, n = 54) that received 30% w/v sucrose solution for 3 months. Subsequently, the C and Ob group were divided into two groups: vehicle (C-Vh and Ob-Vh) that received corn oil as vehicle and tomato lipid extract (C-Ex and Ob-Ex) that received whole tomato lipid extract. The groups that received a hypercaloric diet had a gain in visceral and retroperitoneal adipose tissue, an increase in total cholesterol and triglyceride levels, increased OS in the testis, and lesions in testicular histology, as well as a reduction in testicular size and sperm quality parameters (motility, viability, and concentration).
Treatment with whole tomato lipid extract significantly decreased the weight of gonadal adipose tissue and OS, maintained testicular size, showed a significant increase in sperm quality parameters and improved histology of seminiferous tubules.
These results demonstrate a greater therapeutic and beneficial effect of the tomato lipid extract on sperm quality parameters in obese rats and therefore on fertility.
肥胖是代谢和氧化应激（OS）发展以及男性不育的一个风险因素。目前仍没有针对肥胖诱导的男性不育的药物治疗方法，但有人提出使用天然抗氧化剂进行治疗。
本研究旨在评估全番茄脂质提取物对因高碳水化合物饮食诱导肥胖后生育能力和精子发生降低的大鼠的影响。
使用114只12周龄雄性Wistar大鼠。随机分为两组，非肥胖对照组（C，n = 54）和肥胖组（Ob，n = 54），肥胖组接受30% w/v蔗糖溶液，持续3个月。随后，C组和Ob组再分为两组：接受玉米油作为载体的载体组（C-Vh和Ob-Vh）和接受全番茄脂质提取物的番茄脂质提取物组（C-Ex和Ob-Ex）。接受高热量饮食的组内脏和腹膜后脂肪组织增加，总胆固醇和甘油三酯水平升高，睾丸中的氧化应激增加，睾丸组织学出现病变，睾丸大小和精子质量参数（活力、存活率和浓度）降低。
全番茄脂质提取物治疗显著降低了性腺脂肪组织的重量和氧化应激，维持了睾丸大小，精子质量参数显著增加，并改善了生精小管的组织学。
这些结果表明番茄脂质提取物对肥胖大鼠的精子质量参数以及生育能力具有更大的治疗和有益作用。
