Spoljaritsch C, Frohner K, Podczeck A, Steinbach K
Acta Med Austriaca. 1986;13(2):43-6.
The compliance of 9 patients in taking an antihypertensive therapy was studied by labelling the active substance with riboflavin. The results shows that with a relatively small amount of label it is possible to control the intake of preparations. This is a suitable method for the clinical routine and it allows the direct determination of the elimination of the riboflavin in the urine two hours after the intake of the drug. It is proposed that this method should be used obligatorily in all studies of new drugs for the assessment of their action in the oral long-term therapy. For the daily routine it offers a suitable method for the control of cases where an initial clinical efficiency is followed by therapeutic failures in long-term treatment.
通过用核黄素标记活性物质，研究了9名患者服用抗高血压疗法的依从性。结果表明，使用相对少量的标记物就可以控制制剂的摄入量。这是一种适用于临床常规的方法，并且可以在服药两小时后直接测定尿液中核黄素的消除情况。建议在所有新药研究中强制使用该方法，以评估其在口服长期治疗中的作用。对于日常临床工作，它为控制那些最初临床有效但长期治疗出现治疗失败的病例提供了一种合适的方法。
