Dai Ping, Sun Jin, Yu Zhongkai, Zhang Tongyue, Wen Zixin, Jian Tianzi, Guo Lanlan, Genjiafu Aerbusili, Kan Baotian, Zhang Binbin, Jian Xiangdong
Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Emergency Department, Affiliated the Jianhu Clinical Medical College of Yangzhou University, Yancheng, China.
Front Neurol. 2023 Aug 17;14:1178272. doi: 10.3389/fneur.2023.1178272. eCollection 2023.
Diquat (DQ), chemically known as 1,1 '-ethylene-2,2' -bipyridine, is a non-selective herbicide for leaf removal and drying. It has toxic effects on central nervous system cells, and toxic neurological lesions include axonal degeneration and pontine myelolysis. At the same time, DQ can also affect the activity of dopaminergic nerve cells through oxidative stress, causing degeneration and reducing dopamine uptake. With the increasing application of DQ in agricultural production, the clinical reports of neurotoxicity caused by acute DQ poisoning are also increasing. At present, DQ rapid-phase-related toxic encephalopathy mainly involves the pons, midbrain, basal ganglia, thalamus and other brain regions. However, this case is unusual in that the lesion mainly involved the splenium of the corpus callosum. It is also the first time to be reported.
敌草快（DQ），化学名称为1,1'-亚乙基-2,2'-联吡啶，是一种用于除草和干燥的非选择性除草剂。它对中枢神经系统细胞有毒性作用，神经毒性病变包括轴突变性和脑桥髓鞘溶解。同时，敌草快还可通过氧化应激影响多巴胺能神经细胞的活性，导致变性并减少多巴胺摄取。随着敌草快在农业生产中的应用日益增加，急性敌草快中毒所致神经毒性的临床报告也在增多。目前，与敌草快快速期相关的中毒性脑病主要累及脑桥、中脑、基底节、丘脑等脑区。然而，该病例的不寻常之处在于病变主要累及胼胝体压部。这也是首次报道。
