Li Wenfu, Zhou Hui
Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, China.
Department of Graduate School, Zunyi Medical University, Zunyi, China.
Front Med (Lausanne). 2025 Jun 24;12:1465003. doi: 10.3389/fmed.2025.1465003. eCollection 2025.
Diquat (1,1'-ethylene-2,2'-bipyridine), a non-selective herbicide with significant human toxicity, is increasingly used as a substitute for paraquat in weed management practices in China. Diquat intoxication is typified by multiple organ dysfunction syndrome (MODS), predominantly manifesting as acute renal and hepatic injury, and frequently resulting in central nervous system (CNS) impairment with a poor prognosis in severe instances. Despite the rising incidence of diquat poisoning, the imaging characteristics of diquat-induced toxic encephalopathy remain inadequately documented in the literature. In this report, we present a distinctive case involving a female pediatric patient who exhibited MODS affecting the neurologic, renal, hepatic, cardiac, and gastrointestinal systems, in conjunction with rhabdomyolysis. Magnetic resonance imaging (MRI) revealed multiple abnormal signals in the pons, bilateral brachium pontis, thalamus, caudate nucleus, putamen, posterior part of the external capsule, and posterior limb of the right internal capsule. These findings are consistent with the imaging characteristics of osmotic demyelination syndrome (ODS), which is under-recognized but important. After comprehensive systemic treatment, the patient was discharged on the 30th day post-admission.
敌草快（1,1'-亚乙基-2,2'-联吡啶）是一种对人类有显著毒性的非选择性除草剂，在中国的杂草管理实践中越来越多地被用作百草枯的替代品。敌草快中毒以多器官功能障碍综合征（MODS）为典型特征，主要表现为急性肾损伤和肝损伤，严重时常导致中枢神经系统（CNS）损害，预后不良。尽管敌草快中毒的发生率不断上升，但敌草快所致中毒性脑病 的影像学特征在文献中仍记载不足。在本报告中，我们介绍了一例独特的病例，一名儿科女性患者出现了影响神经、肾、肝、心脏和胃肠道系统的MODS，并伴有横纹肌溶解。磁共振成像（MRI）显示脑桥、双侧脑桥臂、丘脑、尾状核、壳核、外囊后部和右侧内囊后肢有多个异常信号 。这些发现与渗透性脱髓鞘综合征（ODS） 的影像学特征一致，ODS虽未得到充分认识但很重要。经过全面的系统治疗，患者在入院后第30天出院。
